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anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) Antibodies

MASTL encodes a microtubule-associated serine/threonine kinase. Additionally we are shipping MASTL Kits (8) and MASTL Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MASTL 84930 Q96GX5
MASTL 67121 Q8C0P0
Anti-Rat MASTL MASTL 307169  
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Top anti-MASTL Antibodies at antibodies-online.com

Showing 10 out of 79 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells, using MASTL Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IF, WB MASTL  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MASTL antibody detected the MASTL protein (arrow). Confocal immunofluorescent analysis of MASTL Antibody  with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-MASTL AntibodyTitration: 1.0 µg/mL  Positive Control: Fetal Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB Mouse Mastl Antibody (Center) (ABIN658210) western blot analysis in mouse liver tissue lysates (35 µg/lane). This demonstrates the Mastl antibody detected the Mastl protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB MASTL  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MASTL antibody detected the MASTL protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of MASTL Antibody (ABIN652294) in HepG2, MDA-MB231, 293, Hela cell line lysates (35 µg/lane). MASTL (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with MASTL Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 14 Days
$201.19
Details

MASTL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) ,


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Top referenced anti-MASTL Antibodies

  1. Human Polyclonal MASTL Primary Antibody for ELISA, WB - ABIN1534067 : Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: The DNA sequence and comparative analysis of human chromosome 10. ... in Nature 2004 (PubMed)

  2. Human Monoclonal MASTL Primary Antibody for IF, WB - ABIN659139 : Savoia, Del Vecchio, Totaro, Perrotta, Amendola, Moretti, Zelante, Iolascon: An autosomal dominant thrombocytopenia gene maps to chromosomal region 10p. in American journal of human genetics 1999 (PubMed)

More Antibodies against MASTL Interaction Partners

Zebrafish Microtubule Associated serine/threonine Kinase-Like (MASTL) interaction partners

  1. transient knockdown of MASTL correlates with a decrease in the expression of c-mpl (show MPL Antibodies) and GpIIb (show ITGA2B Antibodies), and reduction of circulating thrombocytes

Human Microtubule Associated serine/threonine Kinase-Like (MASTL) interaction partners

  1. Thus, GWL is a human oncoprotein that promotes the hyperactivation of AKT (show AKT1 Antibodies) via the degradation of its phosphatase, PHLPP (show PHLPP1 Antibodies), in human malignancies.

  2. Thus, Fcp1 (show CTDP1 Antibodies) coordinates Cdk1 (show CDK1 Antibodies) and Gwl inactivation to derepress PP2A (show PPP2R4 Antibodies)-B55 (show MINK1 Antibodies), generating a dephosphorylation switch that drives mitosis progression.

  3. Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA (show AURKA Antibodies) network of neuroblastoma (show ARHGEF16 Antibodies).

  4. Data show that siRNA knockdown of Forkhead box M1 (FOXM1 (show FOXM1 Antibodies)) or microtubule-associated serine/threonine kinase-like (MASTL) induces radiosensitivity in non-small cell lung cancer (NSCLC).

  5. Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy

  6. data demonstrate that GWL acts in a pathway with PP2A (show PPP2R4 Antibodies) which is essential for prophase I exit and metaphase I microtubule assembly in mouse oocytes.

  7. Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa (show ENSA Antibodies)/ARPP19 (show ARPP19 Antibodies) and Cdk (show CDK4 Antibodies) substrate dephosphorylation during mitotic exit.

  8. Studies indicate that mutations in three different genes within the THC2 (show ANKRD26 Antibodies) locus have been associated with congenital thrombocytopenia, including a mutation in MASTL.

  9. results identify Gwl as a member of the AGC (show ACAN Antibodies) family of kinases that appears to be regulated by unique mechanisms and that differs from the other members of this family

  10. MASTL enhances cyclin B1 (show CCNB1 Antibodies)-Cdk1 (show CDK1 Antibodies)-dependent mitotic phosphorylation events, directing mitotic entry, anaphase and cytokinesis in human cells.

Mouse (Murine) Microtubule Associated serine/threonine Kinase-Like (MASTL) interaction partners

  1. Mastl is required for the timely activation of anaphase-promoting complex (show CDC26 Antibodies)/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 (show CDK1 Antibodies) activity.

  2. Data show that Mastl (Greatwall)-null cells display mitotic collapse after nuclear envelope breakdown (NEB (show NEB Antibodies)) characterized by defective chromosome condensation and prometaphase arrest.

Xenopus laevis Microtubule Associated serine/threonine Kinase-Like (MASTL) interaction partners

  1. study provides evidence that PP1 (show PPYR1 Antibodies) targets the auto-phosphorylation site of Gwl, resulting in efficient Gwl inactivation; this step is necessary to facilitate subsequent complete dephosphorylation of Gwl by PP2A (show PPP2R2B Antibodies)-B55 (show MINK1 Antibodies)

  2. we showed that the Gwl nuclear localization is indispensable for the biochemical function of Gwl in promoting mitotic entry.

  3. PP2A (show PPP2R2B Antibodies)-B55delta, Greatwall and ARPP19 are not only required for entry into meiotic divisions, but are also pivotal effectors within the Cdk1 (show CDK1 Antibodies) auto-regulatory loop responsible for its independence with respect to the PKA-negative control.

  4. Greatwall kinase and cyclin B-Cdk1 (show CDK1 Antibodies) are both critical constituents of M-phase-promoting factor.

  5. inhibition of PP2A (show PPP2R2B Antibodies)-B55delta results from Ensa (show ENSA Antibodies), that is phosphorylated in mitosis by the protein kinase (show CSNK1D Antibodies) Greatwall; this converts Ensa (show ENSA Antibodies) into specific inhibitor of PP2A (show PPP2R2B Antibodies)-B55delta; this pathway represents a previously unknown element in mitosis control

  6. 3 phosphorylation sites (phosphosites) critical to Gwl activation (pT193, pT206, and pS883 in Xenopus laevis) located in evolutionarily conserved domains that differentiate Gwl from related kinases

  7. Coordinated interplays between Plx1 (show PLK1 Antibodies) and Gwl are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.

  8. mitotic entry and maintenance is not only mediated by the activation of cyclin B-Cdc2 but also by the regulation of PP2A (show PPP2R2B Antibodies) by GW

  9. [review] The kinase Greatwall phosphorylates small protein ARPP-19 and converts it into a potent antimitotic PP2A (show PPP2R2B Antibodies) inhibitor.

MASTL Antigen Profile

Protein Summary

This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.

Gene names and symbols associated with MASTL

  • microtubule associated serine/threonine kinase-like (mastl) antibody
  • microtubule associated serine/threonine kinase-like (MASTL) antibody
  • microtubule associated serine/threonine kinase-like (Mastl) antibody
  • 2700091H24Rik antibody
  • C88295 antibody
  • greatwall antibody
  • GW antibody
  • GWL antibody
  • hGWL antibody
  • im:7149025 antibody
  • MAST-L antibody
  • MASTL antibody
  • RP11-85G18.2 antibody
  • thc2 antibody
  • wu:fa02a12 antibody
  • zgc:100990 antibody

Protein level used designations for MASTL

microtubule-associated serine/threonine-protein kinase-like , serine/threonine-protein kinase greatwall , microtubule associated serine/threonine kinase-like , greatwall protein kinase , Serine/threonine-protein kinase greatwall , Microtubule-associated serine/threonine-protein kinase-like

GENE ID SPECIES
445215 Danio rerio
450367 Pan troglodytes
708134 Macaca mulatta
100441835 Pongo abelii
100514867 Sus scrofa
100541707 Meleagris gallopavo
100602092 Nomascus leucogenys
84930 Homo sapiens
67121 Mus musculus
307169 Rattus norvegicus
540206 Bos taurus
420487 Gallus gallus
607216 Canis lupus familiaris
100464443 Ailuropoda melanoleuca
414585 Xenopus laevis
Selected quality suppliers for anti-MASTL (MASTL) Antibodies
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