Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
MASTL encodes a microtubule-associated serine/threonine kinase. Additionally we are shipping MASTL Antibodies (81) and MASTL Kits (8) and many more products for this protein.
Showing 5 out of 6 products:
transient knockdown of MASTL correlates with a decrease in the expression of c-mpl and GpIIb, and reduction of circulating thrombocytes
Thus, GWL is a human oncoprotein that promotes the hyperactivation of AKT via the degradation of its phosphatase, PHLPP, in human malignancies.
Thus, Fcp1 (show CTDP1 Proteins) coordinates Cdk1 (show CDK1 Proteins) and Gwl inactivation to derepress PP2A (show PPP2R4 Proteins)-B55 (show MINK1 Proteins), generating a dephosphorylation switch that drives mitosis progression.
Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA (show AURKA Proteins) network of neuroblastoma (show ARHGEF16 Proteins).
Data show that siRNA knockdown of Forkhead box M1 (FOXM1 (show FOXM1 Proteins)) or microtubule-associated serine/threonine kinase-like (MASTL) induces radiosensitivity in non-small cell lung cancer (NSCLC).
Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy
data demonstrate that GWL acts in a pathway with PP2A (show PPP2R4 Proteins) which is essential for prophase I exit and metaphase I microtubule assembly in mouse oocytes.
Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa (show ENSA Proteins)/ARPP19 and Cdk (show CDK4 Proteins) substrate dephosphorylation during mitotic exit.
Studies indicate that mutations in three different genes within the THC2 locus have been associated with congenital thrombocytopenia, including a mutation in MASTL.
results identify Gwl as a member of the AGC (show ACAN Proteins) family of kinases that appears to be regulated by unique mechanisms and that differs from the other members of this family
MASTL enhances cyclin B1 (show CCNB1 Proteins)-Cdk1 (show CDK1 Proteins)-dependent mitotic phosphorylation events, directing mitotic entry, anaphase and cytokinesis in human cells.
Mastl is required for the timely activation of anaphase-promoting complex (show CDC26 Proteins)/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 (show CDK1 Proteins) activity.
Data show that Mastl (Greatwall)-null cells display mitotic collapse after nuclear envelope breakdown (NEB) characterized by defective chromosome condensation and prometaphase arrest.
study provides evidence that PP1 (show PPYR1 Proteins) targets the auto-phosphorylation site of Gwl, resulting in efficient Gwl inactivation; this step is necessary to facilitate subsequent complete dephosphorylation of Gwl by PP2A (show PPP2R2B Proteins)-B55 (show MINK1 Proteins)
we showed that the Gwl nuclear localization is indispensable for the biochemical function of Gwl in promoting mitotic entry.
PP2A (show PPP2R2B Proteins)-B55delta, Greatwall and ARPP19 (show ARPP19 Proteins) are not only required for entry into meiotic divisions, but are also pivotal effectors within the Cdk1 (show CDK1 Proteins) auto-regulatory loop responsible for its independence with respect to the PKA-negative control.
Greatwall kinase and cyclin B-Cdk1 (show CDK1 Proteins) are both critical constituents of M-phase-promoting factor.
inhibition of PP2A (show PPP2R2B Proteins)-B55delta results from Ensa (show ENSA Proteins), that is phosphorylated in mitosis by the protein kinase (show CSNK1D Proteins) Greatwall; this converts Ensa (show ENSA Proteins) into specific inhibitor of PP2A (show PPP2R2B Proteins)-B55delta; this pathway represents a previously unknown element in mitosis control
3 phosphorylation sites (phosphosites) critical to Gwl activation (pT193, pT206, and pS883 in Xenopus laevis) located in evolutionarily conserved domains that differentiate Gwl from related kinases
Coordinated interplays between Plx1 and Gwl are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.
mitotic entry and maintenance is not only mediated by the activation of cyclin B-Cdc2 but also by the regulation of PP2A (show PPP2R2B Proteins) by GW
[review] The kinase Greatwall phosphorylates small protein ARPP-19 (show ARPP19 Proteins) and converts it into a potent antimitotic PP2A (show PPP2R2B Proteins) inhibitor.
This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.
microtubule-associated serine/threonine-protein kinase-like
, serine/threonine-protein kinase greatwall
, microtubule associated serine/threonine kinase-like
, greatwall protein kinase
, Serine/threonine-protein kinase greatwall
, Microtubule-associated serine/threonine-protein kinase-like