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The protein encoded by MAPRE2 shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. Additionally we are shipping Microtubule-Associated Protein, RP/EB Family, Member 2 Proteins (10) and many more products for this protein.
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Aurora B (show AURKB Antibodies) and CDK1 (show CDK1 Antibodies) temporally regulate the binding affinity of EB2 for microtubules, thereby ensuring kinetochore microtubule dynamics, proper mitotic progression and genome stability.
Mutations in either TUBB (show TUBB2A Antibodies) or MAPRE2 cause circumferential skin creases Kunze type.
EB2 is evidently important for initial microtubule reorganisation during epithelial polarisation, whereas its downregulation facilitates EB1 and ACF7 microtubule lattice association, microtubule-actin filament co-alignment and bundle formation.
results suggest that EB1 and ClipCG12 act cooperatively to regulate microtubule dynamics (EB1)
heterodimer formation between EB1 and EB3 (show MAPRE3 Antibodies), but not between EB2 and the other two EBs, occurs both in vitro and in cells as revealed by live cell imaging
Data suggest that a functional interaction between EB1 and p150(Glued (show DCTN1 Antibodies)) is required for microtubule minus end anchoring at centrosomes during the assembly and maintenance of a radial microtubule array.
EB1 may modulate kinetochore microtubule polymerization and/or attachment
results support the novel hypothesis that EB1 overexpression may play a role in the development of esophageal squamous cell carcinoma by affecting APC (show APC Antibodies) function and activating the beta-catenin (show CTNNB1 Antibodies)/TCF (show HNF4A Antibodies) pathway
Impaired EB1 or APC (show APC Antibodies) function generates lesions invisible to the spindle checkpoint and thereby promotes low levels of chromosomal loss (CIN (show PDXP Antibodies)) expected to fuel aneuploidy and possibly tumorigenesis.
These data demonstrate that the COP9 (show COPS8 Antibodies) signalosome-dependent protection of EB1 is important for microtubule function.
Knockdown of HAX1 (show HAX1 Antibodies) and EB2 in skin epidermal cells stabilizes focal adhesions and impairs epidermal migration.
Thus, we suggest that EB1 (show MAPRE1 Antibodies) could complement MAP1B (show MAP1B Antibodies) function during neural development.
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants.
microtubule-associated protein, RP/EB family, member 2
, Microtubule-associated protein RP/EB family member 2
, APC-binding protein EB1
, APC-binding protein EB2
, T-cell activation protein, EB1 family
, end-binding protein 2
, microtubule-associated protein RP/EB family member 2
, T-cell activation protein, EB1 family, member 2