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Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Additionally we are shipping Microtubule-Associated Protein, RP/EB Family, Member 3 Antibodies (61) and many more products for this protein.
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Human MAPRE3 Protein expressed in Escherichia coli (E. coli) - ABIN667236
Berrueta, Kraeft, Tirnauer, Schuyler, Chen, Hill, Pellman, Bierer: The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. in Proceedings of the National Academy of Sciences of the United States of America 1998
Show all 2 references for ABIN667236
Human MAPRE3 Protein expressed in Escherichia coli (E. coli) - ABIN2006300
Mimori-Kiyosue, Grigoriev, Lansbergen, Sasaki, Matsui, Severin, Galjart, Grosveld, Vorobjev, Tsukita, Akhmanova: CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. in The Journal of cell biology 2005
Aptamers binding to human EB1 (show MAPRE2 Proteins) and EB3, which have sequence requirements similar to but distinct from each other and from Drosophila EB1 (show MAPRE2 Proteins), were identified.
EB1 (show MAPRE2 Proteins) and EB3 proteins are obligatory dimers.
Findings suggest that methylation-associated down-regulation of EBF3 and IRX1 (show IRX3 Proteins) genes may play an important role in a pathogenic effect of TGF-beta (show TGFB1 Proteins) on RASFs.
Daughter cell adhesion and cytokinesis completion are spatially regulated by distinct states of EB3 phosphorylation on serine 176 by Aurora B (show AURKB Proteins).
decreasing the drebrin E (show DBN1 Proteins) levels disrupted the normal subapical F-actin-myosin-IIB-betaII-spectrin network and the apical accumulation of EB3, a microtubule-plus-end-binding protein
VE-cadherin (show CDH5 Proteins) outside-in signaling regulates cytosolic calcium homeostasis and EB3 phosphorylation.
Data indicated that EB1 (show MAPRE2 Proteins) and EB3 interact with proteins implicated in MT minus-end anchoring or vesicular trafficking to the cilia base, suggesting that EB1 (show MAPRE2 Proteins) and EB3 promote ciliogenesis by facilitating such trafficking.
study found a polycytosine repeat (C8) in exon 5 of MAPRE3 that could be a potential mutation target in cancers with microsatellite instability (MSI (show MSI1 Proteins)); found that the C8 is frequently mutated in gastric and colorectal carcinomas with MSI (show MSI1 Proteins)
heterodimer formation between EB1 (show MAPRE2 Proteins) and EB3, but not between EB2 (show MAPRE2 Proteins) and the other two EBs, occurs both in vitro and in cells as revealed by live cell imaging
neither APC (show APC Proteins) nor p150glued (show DCTN1 Proteins) binding domain is necessary for EB1 (show MAPRE2 Proteins) or EBF3 to induce microtubule bundling
EB3 binds to IP3 receptors, promotes IP3R (show ITPR1 Proteins) clustering and Ca2 (show CA2 Proteins)+ signals in endothelial cells.
MAP1B interacts directly with EB1 (show MAPRE1 Proteins) and EB3 (EBs), two core 'microtubule plus-end tracking proteins' ( TIPs), and sequesters them in the cytosol of developing neuronal cells.
DDA3 (show PSRC1 Proteins) is a novel microtubule-associated protein (show SPAG5 Proteins) that binds to EB3, and results implicate DDA3 (show PSRC1 Proteins) and EB3 in the beta-catenin (show CTNNB1 Proteins)-mediated growth signaling.
Two +TIPs, CLIP-170 and end-binding protein 3 (EB3), turn over rapidly on MT ends. Diffusion of CLIP-170 and EB3 appears to be rate limiting for their binding to MT plus ends.
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
microtubule-associated protein, RP/EB family, member 3
, APC binding protein
, EB1 protein family member 3
, end-binding protein 3
, microtubule-associated protein RP/EB family member 3