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The protein encoded by MID2 is a member of the tripartite motif (TRIM) family. Additionally we are shipping Midline 2 Antibodies (69) and Midline 2 Kits (2) and many more products for this protein.
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Mid2 regulates cell division through the ubiquitination of astrin (show SPAG5 Proteins) on K409, which is critical for its degradation and proper cytokinesis.
A novel missense mutation (c.1040G>A, p.Arg347Gln) was reported in MID2, which encodes ubiquitin ligase E3, as the likely cause of X-linked mental retardation in a large kindred.
MID2 coiled-coil motifs mediate both homo- and heterodimerization, a prerequisite for association of the MID-alpha 4 complex with microtubules.
MID2 is a candidate gene for FG syndrome.
both MID1 (show MID1 Proteins) and MID2 play a central role in the regulation of granule exocytosis and that functional redundancy exists between MID1 (show MID1 Proteins) and MID2 in cytotoxic T cells
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
, ubiquitin ligase
, RING finger protein 60
, midin 2
, midline defect 2
, probable E3 ubiquitin-protein ligase MID2
, tripartite motif protein 1
, tripartite motif-containing protein 1