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MCMBP encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Additionally we are shipping Minichromosome Maintenance Complex Binding Protein Antibodies (25) and many more products for this protein.
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the MCMBP protein accumulates to high levels in cancer cells, whereas in normal proliferating tissue its abundance is low, indicating that MCMBP could be exploited as a novel diagnostic marker for this type of carcinoma.
Data indicate that MCM-BP binds USP7 (show USP7 Proteins) on chromatin and can mediate an interaction between the USP7 (show USP7 Proteins) and MCM proteins.
results suggest that MCM-BP makes multiple contributions to human cells that are not limited to unloading of the MCM complex
MCM-BP can decrease phosphorylation by DDK but is not a substrate.
MCM-BP silencing in human cells also delays MCM dissociation in l (show MCM7 Proteins)ate S phase
MCM-BP is conserved in multicellular eukaryotes and shares limited homology with MCM proteins. MCM-BP formed a complex with MCM3 (show MCM3 Proteins) to MCM7 (show MCM7 Proteins), which excluded MCM2 (show MCM2 Proteins).
Xenopus egg extracts, MCM-BP exists in a stable complex with MCM7 (show MCM7 Proteins), but is not associated with the MCM2-7 (show MCM2 Proteins) hexameric complex
This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene.
, mini-chromosome maintenance complex-binding protein
, minichromosome maintenance complex-binding protein