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Minichromosome Maintenance Deficient 8 Proteins (MCM8)

The protein encoded by MCM8 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. Additionally we are shipping MCM8 Antibodies (56) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MCM8 84515 Q9UJA3
Rat MCM8 MCM8 296178  
MCM8 66634 Q9CWV1
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Top MCM8 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details

MCM8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Top referenced MCM8 Proteins

  1. Human MCM8 Protein expressed in Wheat germ - ABIN1310565 : Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011 (PubMed)

More Proteins for Minichromosome Maintenance Deficient 8 (MCM8) Interaction Partners

Human Minichromosome Maintenance Deficient 8 (MCM8) interaction partners

  1. Suggest role for MCM8 in the pathogenesis of chronic myelogenous leukemia.

  2. MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These

  3. An autosomal recessive ovarian failure disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic instability.

  4. Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 (show MCM9 Proteins) proteins are rapidly recruited to DNA damage sites and promote RAD51 (show RAD51 Proteins) recruitment.

  5. Single Nucleotide Polymorphism in MCM8 is associated with ovarian follicle number and menopause.

  6. Single nucleotide polymorphism in MCM8 is associated with menopause and the length of reproductive lifespan.

  7. The MCM8 gene is located contrapodal to GCD10 at chromosome band 20p12.3-13.

  8. MCM8 is a crucial component of the pre-RC and that the interaction between hMCM8 and hcdc6 is required for pre-RC assembly.

  9. We find that MCM8, like MCM7 (show MCM7 Proteins), colocalizes on a specific DNA segment of the c-MYC (show MYC Proteins) replication initiation zone (c-MYC (show MYC Proteins) replicator) of DNA replications together with Cdc6 (show CDC6 Proteins) and cdk2 (show CDK2 Proteins), but differs with MCM7 (show MCM7 Proteins) in spatial relation to RPA70 (show RPA1 Proteins) during S phase.

Xenopus laevis Minichromosome Maintenance Deficient 8 (MCM8) interaction partners

  1. Mcm8 and Mcm9 (show MCM9 Proteins) form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation.

  2. MCM8 functions in the elongation step of DNA replication as a helicase that facilitates the recruitment of RPA34 and stimulates the processivity of DNA polymerases at replication foci.

Mouse (Murine) Minichromosome Maintenance Deficient 8 (MCM8) interaction partners

  1. MCM8 and MCM9 (show MCM9 Proteins) form a complex and that they coregulate their stability.

MCM8 Protein Profile

Protein Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with MCM8

  • minichromosome maintenance complex component 8 (MCM8)
  • minichromosome maintenance complex component 8 (Mcm8)
  • minichromosome maintenance complex component 8 (mcm8)
  • minichromosome maintenance deficient 8 (S. cerevisiae) (Mcm8)
  • 5730432L01Rik protein
  • C20orf154 protein
  • dJ967N21.5 protein

Protein level used designations for MCM8

DNA helicase MCM8 , DNA replication licensing factor MCM8 , MCM8 minichromosome maintenance deficient 8 , REC homolog , minichromosome maintenance 8 , minichromosome maintenance deficient 8 , Minichromosome maintenance 8

GENE ID SPECIES
84515 Homo sapiens
421314 Gallus gallus
477163 Canis lupus familiaris
507507 Bos taurus
296178 Rattus norvegicus
734487 Xenopus laevis
66634 Mus musculus
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