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Mitochondrial Calcium Uniporter Proteins (MCU)

MCU encodes a calcium transporter that localizes to the mitochondrial inner membrane. Additionally we are shipping MCU Kits (20) and MCU Antibodies (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MCU 90550 Q8NE86
MCU 215999 Q3UMR5
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Top MCU Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MCU Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

More Proteins for Mitochondrial Calcium Uniporter (MCU) Interaction Partners

Human Mitochondrial Calcium Uniporter (MCU) interaction partners

  1. Our experiments provide novel details about how MCU/EMRE is regulated by MICU1 (show MICU1 Proteins) and an original approach to investigate MCU/EMRE activation in intact cells.

  2. Data suggest that MCU regulator (EMRE) might be a structural factor for opening of the mitochondrial calcium uniporter (MCU)-forming pore.

  3. results suggest that N terminal domain of MCU is essential for the modulation of MCU function, although it does not affect the uniplex formation

  4. MCU-VDAC1 (show VDAC1 Proteins) complex regulates mitochondrial Ca(2 (show CA2 Proteins)+) uptake and oxidative stress-induced (show SQSTM1 Proteins) apoptosis

  5. Loss of heterozygosity of MCU gene on chromosome 10q is associated with pancreatic cancer.

  6. Studies indicate the existence of an inner mitochondrial protein (show COX6B2 Proteins) termed the mitochondrial calcium uniporter for calcium transport.

  7. analyses establish that MCU encodes the pore-forming subunit of the uniporter channel

  8. MCU plays a critical role in breast cancer cell migration by regulating store-operated Ca(2 (show CA2 Proteins)) entry.

  9. SLC25A23 (show SLC25A24 Proteins) augments mitochondrial Ca(2 (show CA2 Proteins)) uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

  10. We review not only the biochemical identities and structures of the proteins required for mitochondrial Ca2 (show CA2 Proteins)+ uptake but also their implications in different physiopathological contexts. [review]

Mouse (Murine) Mitochondrial Calcium Uniporter (MCU) interaction partners

  1. the Mcu-regulating Micu gene family profile differs substantially between neurons and astrocytes, while expression of Mcu itself is markedly different between CA3 (show CA3 Proteins) and CA1 (show CA1 Proteins) regions in the adult hippocampus.

  2. Absence of MCU expression does not affect basal cardiac function at either 12 or 20months of age in knockout mice.

  3. MCU is required to match energetics with contractile demand during stress. Deletion of Mcu protects against myocardial IR injury.

  4. Mice lacking MCU in the heart show no pathology. MCU selectively mediates acute mitochondria Ca2 (show CA2 Proteins)+ loading to augment ATP synthesis.

  5. MCU is necessary for complete physiological heart rate acceleration

  6. MCU-VDAC1 (show VDAC1 Proteins) complex regulates mitochondrial Ca(2 (show CA2 Proteins)+) uptake and oxidative stress-induced (show SQSTM1 Proteins) apoptosis

  7. Chromatin immunoprecipitation and promoter reporter analyses revealed that the Ca2 (show CA2 Proteins)+ -regulated transcription factor CREB (show CREB1 Proteins) (cyclic adenosine monophosphate response element-binding protein) directly bound the MCU promoter and stimulated expression.

  8. chronic myocardial MCU inhibition leads to previously unanticipated compensatory changes.

  9. Tetrodotoxin-sensitive mitochondrial Ca(2 (show CA2 Proteins)+) influx was largely blocked by knockdown of MCU expression.

  10. Characterization of MCU deficient mice indicates that acute alterations in mitochondrial matrix calcium can regulate mammalian physiology.

MCU Protein Profile

Protein Summary

This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with MCU

  • mitochondrial calcium uniporter (MCU)
  • mitochondrial calcium uniporter (Mcu)
  • 2010012O16Rik protein
  • AV064928 protein
  • C10orf42 protein
  • Ccdc109a protein
  • D130073L02Rik protein
  • Gm64 protein

Protein level used designations for MCU

calcium uniporter protein, mitochondrial , coiled-coil domain-containing protein 109A , coiled-coil domain containing 109A

GENE ID SPECIES
90550 Homo sapiens
215999 Mus musculus
489042 Canis lupus familiaris
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