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This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. Additionally we are shipping Mitochondrial Fission Factor Antibodies (49) and Mitochondrial Fission Factor Proteins (7) and many more products for this protein.
We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations
membrane-anchored Mff differentially regulates various Drp1 (show CRMP1 ELISA Kits) isoforms.
Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC).
loss of Mff results in failure of Parkin (show PARK2 ELISA Kits) translocation and final clearance of damaged mitochondria
Mitochondrial fission factor (MFF) mRNA is a direct target of miR (show MLXIP ELISA Kits)-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region.
MiD49 (show SMCR7 ELISA Kits) and MiD51 (show SMCR7L ELISA Kits) can act independently of Mff and Fis1 (show FIS1 ELISA Kits) in Drp1 (show CRMP1 ELISA Kits) recruitment and suggest that they provide specificity to the division of mitochondria.
TRAP1 (show TRAP1 ELISA Kits) controls mitochondrial fusion/fission balance through Drp1 (show CRMP1 ELISA Kits) and Mff expression.
PEX11 proteins attract both Mff and human Fis1 (hFis1 (show FIS1 ELISA Kits)) to their site of action.
MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS (show ROS1 ELISA Kits) production, and the onset of autophagy and mitophagy.
MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
Mff cannot bind to assembly-deficient mutants of Drp1 (show CRMP1 ELISA Kits), suggesting that Mff selectively interacts with higher-order complexes of Drp1 (show CRMP1 ELISA Kits).
These findings provide a mechanism wherein the multimeric states of both Mff and Drp1 (show CRMP1 ELISA Kits) regulate their collaborative interaction.
Ablating Mfn1 (show MFN1 ELISA Kits) eliminates the cardiac-related lethality of Mff knockout mice.
Mitochondrial fission factor has been identified as a new AMPK (show PRKAA1 ELISA Kits) substrate.
This study reveals a novel model of mitochondrial fission regulation, which is composed of miR (show MLXIP ELISA Kits)-761 and mitochondrial fission factor
immunofluorescence analysis of Drp1 (show CRMP1 ELISA Kits) suggests that Fis1 (show FIS1 ELISA Kits) and Mff are important for the number and size of Drp1 (show CRMP1 ELISA Kits) puncta on mitochondria.
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants.
mitochondrial fission factor homolog B
, mitochondrial fission factor homolog A
, mitochondrial fission factor
, Uncharacterized protein C2orf33 homolog