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The protein encoded by MTPAP is a member of the DNA polymerase type-B-like family. Additionally we are shipping Mitochondrial Poly(A) Polymerase Antibodies (9) and Mitochondrial Poly(A) Polymerase Kits (3) and many more products for this protein.
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Mitochondrial poly(A) polymerase is able to add the discriminator adenosine to tRNATyr.
The polymerase activity of mtPAP is modulated by LRPPRC (show LRPPRC Proteins)/SLIRP; N478D mtPAP mutation decreases its activity and the alteration in poly(A) length causes dysregulation of post-transcriptional expression and lack of respiratory chain complexes.
Mutation of the MTPAP gene results in a cellular phenotype of increased DNA damage, reduced repair kinetics, increased cell death by apoptosis, and reduced clonogenic survival after exposure to ionizing radiation.
show that dimerization is required for the catalytic activity of PAPD1
Characterization of this marker shows that it is orthologous to the human gene KIAA1462 located on HSA10p11.23, where a major quantitative trait locus for morbid obesity has been reported.
Cloning of a human nuclear-encoded mitochondrial poly(A) polymerase (hmtPAP)that has a role in mitochondrial RNA processing.
The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.
PAP-associated domain-containing protein 1
, TUTase 1
, poly(A) RNA polymerase, mitochondrial
, polynucleotide adenylyltransferase
, terminal uridylyltransferase 1
, PAP associated domain containing 1