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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Additionally we are shipping Mitochondrial Ribosomal Protein L12 Kits (8) and Mitochondrial Ribosomal Protein L12 Proteins (6) and many more products for this protein.
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Human Monoclonal MRPL12 Primary Antibody for IF, IHC (p) - ABIN562710
Wang, Cotney, Shadel: Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. in The Journal of biological chemistry 2007
Show all 3 references for ABIN562710
knock-down of MRPL12 by RNA interference results in instability of POLRMT (show POLRMT Antibodies).
This mutation resulted in a decreased steady-state level of MRPL12 protein.
the MRPL12 interaction with POLRMT (show POLRMT Antibodies) is likely part of a novel regulatory mechanism that coordinates mitochondrial transcription with translation
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.
39S ribosomal protein L12, mitochondrial
, mitochondrial ribosomal protein L12
, likely mitochondrial ribosomal protein (E. coli L7/L12)
, ribosomal protein, mitochondrial, L12