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Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Additionally we are shipping Mitochondrially Encoded NADH Dehydrogenase 3 Antibodies (28) and and many more products for this protein.
Disruption of FASTKD1 increases ND3 mRNA level. Disruption of FASTKD4 (show TBRG4 ELISA Kits) reduces it. Very low levels of FASTKD4 (show TBRG4 ELISA Kits) are sufficient to prevent ND3 loss.
In the current study, we first took clinical and molecular datasets from case-control studies to determine the association between the ND3 G10398A mutation and breast cancer.
Earlier age at onset was noted in male Chinese Machado-Joseph disease patients with MT-ND3 gene 10398A polymorphism
Study identified cancer-specific somatic variants in the ND2 (show MT-ND2 ELISA Kits) and ND3 regions, and the presence of these mutated DNAs in the serum during the postoperative period accurately predicted poor prognoses in oral squamous cell carcinomas.
Hypoxia, oxidative stress, and saturated fatty acids impacted mitochondrial-mediated cell apoptosis and had promotion on MT-ND3 expression in hepatocytes.
Point mutations m.10191T>C in mitochondrial ND3 gene, m.13513G>A in ND5 (show MT-ND5 ELISA Kits) gene and m.14,453G>A in ND6 (show MT-ND6 ELISA Kits) gene were detected in three Chinese children with Leigh synrome dur to complex I deficiency.
mitochondrial ND3 gene mutation may have a role in causing in Leigh syndrome with early lethality
This is the first description of infantile Leigh syndrome due to a maternally transmitted T10191C substitution in ND3 and not due to a de novo mutation.
These results show that the 10197G>A mutation in the mitochondrial ND3 gene should be considered as a common mtDNA mutation responsible for Leigh syndrome and dystonia.
study reports a novel heteroplasmic m.10197G>A mutation in the ND3 gene in three Korean children with bilateral basal ganglia lesions and partial deficiencies of respiratory chain complex I activity
Data indicate that in the D-form of complex I the ND3 subunit crosslinked to the 39 kDa (NDUFA9 (show NDUFA9 ELISA Kits)) subunit.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
NADH dehydrogenase subunit 3