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Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Additionally we are shipping Mitochondrially Encoded NADH Dehydrogenase 6 Antibodies (20) and and many more products for this protein.
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Protein modeling revealed loss of function mutations of ND6 and COX (show COX8A ELISA Kits)-II proteins in malignant vs benign tumors
Liver MT-ND6 transcriptional activity and protein expression were decreased in nonalcoholic steatohepatitis, suggesting that the expression of this mitochondrial gene may play an important role in the disease progression.
Point mutations m.10191T>C in mitochondrial ND3 (show MT-ND3 ELISA Kits) gene, m.13513G>A in ND5 (show MT-ND5 ELISA Kits) gene and m.14,453G>A in ND6 gene were detected in three Chinese children with Leigh synrome dur to complex I deficiency.
These data suggested that the ND6 T14502C variant may modulate the phenotypic manifestation of the G11778A mutation in these Chinese pedigrees.
mitochondrial ND6 may have a role in Leber's hereditary optic neuropathy
Free radicals-mediated damage was studied in transmitochondrial cells harboring T14487C mutation in the ND6 gene of mtDNA.
Therefore, the coexistence of the A1555G mutation and T14484C mutations in this Chinese family indicate that the A1555G mutation may play a synergistic role in the phenotypic manifestation of LHON associated ND6 T14484C mutation.
T14484C and T14502C in ND6 gene are associated with Leber's hereditary optic neuropathy in a Chinese family.
G10680A mutation of ND4 (show MT-ND4 ELISA Kits) may play a synergistic role with the primary mutation T14484C of ND6, leading to the complete penetrance of Leber's hereditary optic neuropathy in the presenting family.
Molecular analysis has led to identification of the known T14502C mutation in ND6 gene in Chinese families with Leber's hereditary optic neuropathy.
Data suggest that expression of ND6 in adipose tissue can be regulated by dietary factors; here, expression of ND6 in mitochondria of white adipose tissue is down-regulated in obesity caused by high-fat diet.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
NADH dehydrogenase subunit 6