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The protein encoded by MFN1 is a mediator of mitochondrial fusion. Additionally we are shipping Mitofusin 1 Proteins (11) and Mitofusin 1 Kits (4) and many more products for this protein.
Showing 10 out of 136 products:
Human Monoclonal MFN1 Primary Antibody for RNAi, ELISA - ABIN527615
Zanna, Ghelli, Porcelli, Karbowski, Youle, Schimpf, Wissinger, Pinti, Cossarizza, Vidoni, Valentino, Rugolo, Carelli: OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. in Brain : a journal of neurology 2008
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Mouse (Murine) Monoclonal MFN1 Primary Antibody for ICC, IF - ABIN4334757
White, Puppa, Sato, Gao, Price, Baynes, Kostek, Matesic, Carson: IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse. in Skeletal muscle 2012
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Human Polyclonal MFN1 Primary Antibody for ICC, IF - ABIN4334755
Miller, Knaub, Olivera-Fragoso, Keller, Balasubramaniam, Watson, Reusch: Nitric oxide regulates vascular adaptive mitochondrial dynamics. in American journal of physiology. Heart and circulatory physiology 2013
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Human Polyclonal MFN1 Primary Antibody for FACS, IF (p) - ABIN670071
Lou, Guan, Liu, Liu, Zhang, Pan, Pei: The influence of chronic fluorosis on mitochondrial dynamics morphology and distribution in cortical neurons of the rat brain. in Archives of toxicology 2013
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Human Polyclonal MFN1 Primary Antibody for EIA, WB - ABIN953454
Perumalsamy, Nagala, Sarin: Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival. in Proceedings of the National Academy of Sciences of the United States of America 2010
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Cow (Bovine) Polyclonal MFN1 Primary Antibody for WB - ABIN2787347
Bonala, McFarlane, Ang, Lim, Lee, Chua, Lokireddy, Sreekanth, Leow, Meng, Shyong, Lee, Gluckman, Sharma, Kambadur: Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity. in Molecular endocrinology (Baltimore, Md.) 2013
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The results showed that high level of Mfn1 expression significantly improved the embryo development rates by increasing ATP level and Deltapsim, while reducing H(2)O(2) generation.
MFN1-positive expression could be seen mainly in ganglion cells after 1 week of minus lens intervention, and with time extension, more and more positive cells appeared in the rod-cone cell and bipolar cell layer, and this phenomenon could not be found in the normal control eyes.
crystal structures of engineered human MFN1 containing the GTPase (show RACGAP1 Antibodies) domain and a helical domain during different stages of GTP (show AK3 Antibodies) hydrolysis; mechanistic model for MFN1-mediated mitochondrial tethering is proposed; results shed light on the molecular basis of mitochondrial fusion and mitofusin (show MFN2 Antibodies)-related human neuromuscular disorders
These results suggest that MFN (show TLL1 Antibodies) tethers apposing membranes, likely through nucleotide-dependent dimerization.
Improper transcriptional (in)activation of mitofusin-1 and dynamin-related protein 1 (show DNM1L Antibodies) during early in vitro embryo development is associated with a decrease in mitochondrial membrane potential and with embryo fragmentation.
A fine balance of Mfn1 levels is maintained by MARCH5 (show MARCH5 Antibodies)-mediated quality control on acetylated Mfn1.
miR (show MLXIP Antibodies)-19b targets 3'UTR (show UTS2R Antibodies) sequences of Mfn1 genes inhibit the expression of Mfn1
In a amyotrophic lateral sclerosis transgenic mouse model, Mfn1 is significantly increased in spinal cord.
A novel role for the endoplasmic reticulum-associated Gp78 (show AMFR Antibodies) ubiquitin ligase and the Mfn1 mitochondrial fusion factor in mitophagy.
Knock-out of mitofusin (show MFN2 Antibodies) protein Mfn1 increased the frequency of mitochondrial fission with increased lifetime of unpaired events whereas deletion of both Mfn1 and Mfn2 (show MFN2 Antibodies) resulted in an instable dynamics.
These results collectively suggest a role for Mfn1 in regulating the activation of Bax (show BAX Antibodies) on the outer mitochondrial membrane in a GTPase (show RACGAP1 Antibodies)-dependent manner.
We found that mouse embryonic fibroblasts lacking Mfn2 (show MFN2 Antibodies) have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 (show MFN2 Antibodies) does not have a role in adipocyte differentiation.
MFN1 deficiency leads to defects in mitochondrial activity and male infertility.
Report exposes a novel role for Shh (show SHH Antibodies) in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 and 2.
Ablating Mfn1 eliminates the cardiac-related lethality of Mff (show MFF Antibodies) knockout mice.
Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: Mfn1, Mfn2 (show MFN2 Antibodies), OPA1 (optic atrophy 1 (show OPA1 Antibodies) protein), and Drp1 (dynamin 1-like protein (show DNM1L Antibodies)). [REVIEW]
Authors present evidence that metabolically challenged mitochondria undergo active fusion to suppress oxidative stress. In response to glucose starvation, mitofusin 1 (MFN1) becomes associated with the protein deacetylase HDAC6 (show HDAC6 Antibodies).
These findings suggest that mitochondrial impairment is a very early event in Alzheimer disease pathogenesis and abnormal expression of Mfn1 and Mfn2 (show MFN2 Antibodies) caused by excessive intracellular Abeta (show APP Antibodies) is the possible molecular mechanism.
Data identify MFN1 as an ERK (show EPHB2 Antibodies) target to modulate mitochondrial shape and apoptosis.
Mitochondrial shape governs BAX (show BAX Antibodies)-induced membrane permeabilization and apoptosis via Mfn1.
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.
, mitofusin 2
, fzo homolog
, mitochondrial transmembrane GTPase FZO-2
, mitochondrial transmembrane GTPase Fzo-1
, putative transmembrane GTPase
, transmembrane GTPase MFN1
, mitochondrial transmembrane GTPase FZO1B