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The protein encoded by MFN1 is a mediator of mitochondrial fusion. Additionally we are shipping Mitofusin 1 Antibodies (138) and Mitofusin 1 Kits (5) and many more products for this protein.
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The results showed that high level of Mfn1 expression significantly improved the embryo development rates by increasing ATP level and Deltapsim, while reducing H(2)O(2) generation.
Regulation of Mfn1 by MGRN1 (show MGRN1 Proteins) and the proteasome modulates mitochondrial fusion.
SLC25A46 (show SLC25A46 Proteins) is a new component in mitochondrial dynamics that serves as a regulator for MFN1/2 oligomerization.
MFN1-positive expression could be seen mainly in ganglion cells after 1 week of minus lens intervention, and with time extension, more and more positive cells appeared in the rod-cone cell and bipolar cell layer, and this phenomenon could not be found in the normal control eyes.
crystal structures of engineered human MFN1 containing the GTPase (show RACGAP1 Proteins) domain and a helical domain during different stages of GTP (show AK3 Proteins) hydrolysis; mechanistic model for MFN1-mediated mitochondrial tethering is proposed; results shed light on the molecular basis of mitochondrial fusion and mitofusin (show MFN2 Proteins)-related human neuromuscular disorders
These results suggest that MFN (show TLL1 Proteins) tethers apposing membranes, likely through nucleotide-dependent dimerization.
Improper transcriptional (in)activation of mitofusin-1 and dynamin-related protein 1 (show DNM1L Proteins) during early in vitro embryo development is associated with a decrease in mitochondrial membrane potential and with embryo fragmentation.
A fine balance of Mfn1 levels is maintained by MARCH5 (show MARCH5 Proteins)-mediated quality control on acetylated Mfn1.
miR (show MLXIP Proteins)-19b targets 3'UTR sequences of Mfn1 genes inhibit the expression of Mfn1
In a amyotrophic lateral sclerosis transgenic mouse model, Mfn1 is significantly increased in spinal cord.
A novel role for the endoplasmic reticulum-associated Gp78 (show AMFR Proteins) ubiquitin ligase and the Mfn1 mitochondrial fusion factor in mitophagy.
These results highlight the crucial role of MFN1 in maintaining the competency of the STING pathway.
Despite apparent mitochondrial dysfunction, hearts deficient in both Mfn1 and Mfn2 (show MFN2 Proteins) are protected against acute myocardial infarction due to impaired mitochondria/sarcoplasmic reticulum tethering.
We found that mouse embryonic fibroblasts lacking Mfn2 (show MFN2 Proteins) have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 (show MFN2 Proteins) does not have a role in adipocyte differentiation.
MFN1 deficiency leads to defects in mitochondrial activity and male infertility.
Report exposes a novel role for Shh (show SHH Proteins) in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 and 2.
Ablating Mfn1 eliminates the cardiac-related lethality of Mff (show MFF Proteins) knockout mice.
Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: Mfn1, Mfn2 (show MFN2 Proteins), OPA1 (optic atrophy 1 (show OPA1 Proteins) protein), and Drp1 (dynamin 1-like protein (show DNM1L Proteins)). [REVIEW]
Authors present evidence that metabolically challenged mitochondria undergo active fusion to suppress oxidative stress. In response to glucose starvation, mitofusin 1 (MFN1) becomes associated with the protein deacetylase HDAC6 (show HDAC6 Proteins).
These findings suggest that mitochondrial impairment is a very early event in Alzheimer disease pathogenesis and abnormal expression of Mfn1 and Mfn2 (show MFN2 Proteins) caused by excessive intracellular Abeta (show APP Proteins) is the possible molecular mechanism.
Data identify MFN1 as an ERK (show EPHB2 Proteins) target to modulate mitochondrial shape and apoptosis.
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.
, mitofusin 2
, fzo homolog
, mitochondrial transmembrane GTPase FZO-2
, mitochondrial transmembrane GTPase Fzo-1
, putative transmembrane GTPase
, transmembrane GTPase MFN1
, mitochondrial transmembrane GTPase FZO1B