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Mitofusin 2 Proteins (MFN2)

MFN2 encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. Additionally we are shipping Mitofusin 2 Antibodies (151) and Mitofusin 2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MFN2 9927 O95140
MFN2 170731 Q80U63
MFN2 64476  
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Top Mitofusin 2 Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MFN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Mitofusin 2 (MFN2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitofusin 2 (MFN2) interaction partners

  1. Marf is required for mitochondrial fusion and transport in long axons.

  2. Expression of Mfn2 and endoplasmic reticulum (ER) stress reduction in flies lacking Marf corrected ER shape, attenuating the developmental and motor defects.

  3. Parkin (show PARK2 Proteins) deficiency and resulting mitophagic disruption produces cardiomyopathy which can be contained by suppressing mitofusin.

  4. mfn2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology

  5. Data report here that Drosophila Reaper can induce mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf.

  6. MARF and Opa1 (show OPA1 Proteins) control mitochondrial and cardiac function in Drosophila.

  7. The PINK1 (show PINK1 Proteins)/Parkin (show PARK2 Proteins) pathway affects mitochondrial fission/fusion as suggested by previous genetic interaction studies.

  8. Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut (show GUSB Proteins) development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line.

Human Mitofusin 2 (MFN2) interaction partners

  1. This study demonstrated that Mfn2 gene polymorphisms were associated with essential hypertension in northern Han Chinese population, especially in male subjects

  2. Report exposes a novel role for Shh (show SHH Proteins) in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 (show MFN1 Proteins) and 2.

  3. family study of early onset severe axonal Charcot-Marie-Tooth disease with dominant inheritance - SNP mutation in MFN2

  4. Our findings provide new insight into the mechanism underlying Mitofusin-2 regulation and the potential role of miR (show MLXIP Proteins)-761 in tocellular carcinoma, making it a potential candidate for use in HCC (show FAM126A Proteins) therapy in the future

  5. HMGB1 (show HMGB1 Proteins) can trigger apoptosis of T lymphocytes through mitochondrial death pathway associated with [Ca(2 (show CA2 Proteins)+)]i elevation. Mfn2 plays a pivotal role in this process, and it might be a novel therapeutic target in T cell apoptosis related disorders.

  6. Mutations in the gene encoding MFN2 are associated with Charcot-Marie-Tooth disease type 2A and MFN2 is involved in several intracellular pathways that interact to regulate the mitochondrial network within cells.

  7. These findings show that homozygous mutations at p.R707W in MFN2 are a novel cause of multiple symmetrical lipomatosis.

  8. A deletion of exons 7 and 8 is a founder mutation in MFN2 in the UK population.

  9. increased expression of miR (show MLXIP Proteins)-214 observed in a Huntington disease (show HTT Proteins) cell model could target MFN2, altered mitochondrial morphology and deregulated cell cycle

  10. Mitofusin-2 over-expression leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma.

Mouse (Murine) Mitofusin 2 (MFN2) interaction partners

  1. SIRT1 (show SIRT1 Proteins) overexpression substantially increased autophagy in wild-type cells, but not in MFN2-deficient cells.

  2. mitofusin 2 overexpression may attenuate hypoxia-induced apoptosis.

  3. Mitofusin 2, in addition to its role in mitochondrial fusion, is important for maintaining coenzyme Q levels and may be an integral player in the mevalonate synthesis pathway.

  4. suggest a balance between negative metabolic consequences of mitofusin 2 deficiency and adaptive processes exemplified by increased level of PGC-1alpha and TFAM (show TFAM Proteins) transcription factor which prevent an depletion of mtDNA and severe impairment of cell metabolism

  5. Our results indicate that HDAC6 (show HDAC6 Proteins) is a critical regulator of MFN2 degradation by MARCH5 (show MARCH5 Proteins), thus protecting mitochondrial connectivity from hypoxic stress.

  6. Mfn2 attenuates the blastocyst formation rate and cleavage speed in mouse zygotes and causes mitochondrial dysfunction, as confirmed by the ATP and mtDNA levels and mitochondrial membrane potential.

  7. Mfn2 is specifically required for the maintenance of hematopoietic stem cells (HSCs) with extensive lymphoid potential, but not, or less so, for the maintenance of myeloid-dominant HSCs

  8. confirm the hypothesis that the cellular consequences of mutations in the mitofusin 2 gene can mostly be manifested in the peripheral nervous system

  9. Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: Mfn1 (show MFN1 Proteins), Mfn2, OPA1 (optic atrophy 1 (show OPA1 Proteins) protein), and Drp1 (dynamin 1-like protein (show DNM1L Proteins)). [REVIEW]

  10. Results suggest that Mfn2 and OPA1 are upregulated during bone marrow progenitor differentiation and promote the migration of immature dendritic cells by regulating the expression of CCR7 (show CCR7 Proteins).

Zebrafish Mitofusin 2 (MFN2) interaction partners

  1. These results highlight the essential role of mitofusin 2 in the motor axon development and demonstrate the potential of zebrafish as a suitable and complementary platform for dissecting pathogenetic mechanisms of MFN2 mutations in vivo.

Cow (Bovine) Mitofusin 2 (MFN2) interaction partners

  1. A highly unusual splicing defect, where an exonic single base exchange leads to the retention of the preceding intron, was identified in MFN2 (show MFN1 Proteins).

Mitofusin 2 (MFN2) Protein Profile

Protein Summary

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Gene names and symbols associated with Mitofusin 2 Proteins (MFN2)

  • mitofusin 2 (MFN2)
  • Mitochondrial assembly regulatory factor (Marf)
  • mitofusin 2 (mfn2)
  • mitofusin 2 (Mfn2)
  • mitofusin 2 (LOC100350119)
  • anon-WO0125274.3 protein
  • CG3869 protein
  • CMT2A protein
  • CMT2A2 protein
  • CPRP1 protein
  • D630023P19Rik protein
  • Dmel\\CG3869 protein
  • dmfn protein
  • Fzo protein
  • HSG protein
  • marf protein
  • Marf-1 protein
  • mfn protein
  • MFN2 protein
  • mg:cb01g09 protein
  • si:dkeyp-104h9.2 protein
  • wu:fb79a11 protein

Protein level used designations for Mitofusin 2 Proteins (MFN2)

CG3869-PA , CG3869-PB , CG3869-PC , Marf-PA , Marf-PB , Marf-PC , drosophila mitofusin , mitochondrial assembly regulatory factor , mitofusin , mitofusin 2 , mitofusin-2 , mitofusin-2-like , hyperplasia suppressor , transmembrane GTPase MFN2 , HSG protein , hypertension related protein 1 , hypertension-related protein 1 , hypertension-related protein , mitochondrial transmembrane GTPase FZO1A

GENE ID SPECIES
100055966 Equus caballus
31581 Drosophila melanogaster
457958 Pan troglodytes
549268 Xenopus (Silurana) tropicalis
100172672 Pongo abelii
100186475 Ciona intestinalis
100427191 Macaca mulatta
100470367 Ailuropoda melanoleuca
100599174 Nomascus leucogenys
9927 Homo sapiens
170731 Mus musculus
64476 Rattus norvegicus
567448 Danio rerio
431918 Xenopus laevis
419484 Gallus gallus
487439 Canis lupus familiaris
534574 Bos taurus
100350119 Oryctolagus cuniculus
100512172 Sus scrofa
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