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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additionnal targets (By similarity).
MAP kinase 14B
, MAP kinase p38b
, MAPK 14B
, mitogen-activated protein kinase 14B
, mitogen-activated protein kinase p38b