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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Additionally we are shipping MAP3K9 Antibodies (72) and many more products for this protein.
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identified three kinases with gain-of-function mutations in lung cancer, namely FGFR4 (show FGFR4 Proteins), MAP3K9, and PAK5 (show PAK6 Proteins). Mutations in these kinases are activating toward the ERK (show EPHB2 Proteins) pathway, and targeted depletion of the mutated kinases inhibits proliferation
It was found that 24% of melanoma cell lines have mutations in the protein-coding regions of either MAP3K5 (show MAP3K5 Proteins) or MAP3K9.
estrogen receptor-alpha (show ESR1 Proteins) transcriptional activity is repressed by the Rho/megakaryoblastic leukemia 1 signaling pathway
These results show that the expression of nucleosomal SRF-dependent genes, including the SMC gene, is activated by MKL1 via activation of SRF and recruitment of the FACT complex.
There is extensive functional redundancy between MLK1 and MLK2 (show MAP3K10 Proteins), and the other member of the family, MLK3, none of which are required for survival in mouse.
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
mixed lineage kinase 1 (tyr and ser/thr specificity)
, mitogen activated protein kinase kinase kinase 9
, mixed-lineage kinase 1