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The protein encoded by MAP4K2 is a member of the serine/threonine protein kinase family. Additionally we are shipping MAP4K2 Antibodies (77) and many more products for this protein.
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These studies demonstrate, for the first time, that GCK (show GCK Proteins) is a molecular therapeutic target in DLBCL tumors and that inhibiting GCK (show GCK Proteins) may significantly extend DLBCL patient survival.
Data indicate 4-substituted 1H-pyrrolo[2,3-b]pyridines as potent inhibitors against TGFbeta (show TGFB1 Proteins)-activated kinase 1 (TAK1 (show MAP3K7 Proteins)) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2).
Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB.
Data suggest that the Rabin8-Rab8 (show RAB8A Proteins)-Sec15 (show EXOC6 Proteins) interaction may couple the activation of Rab8 (show RAB8A Proteins) to the recruitment of the Rab8 (show RAB8A Proteins) effector and is involved in the regulation of vesicular trafficking for primary cilium formation.
CCM3 (show PDCD10 Proteins) is located on the Golgi apparatus, forming a complex with proteins of the germinal center kinase III (GCKIII) family and GM130 (show GOLGA2 Proteins), a Golgi-resident protein.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
B lymphocyte serine/threonine protein kinase
, MAPK/ERK kinase kinase kinase 2
, MEK kinase kinase 2
, MEKKK 2
, Rab8 interacting protein
, germinal centre kinase (GC kinase)
, RAB8 interacting protein
, germinal center kinase
, mitogen activated protein kinase kinase kinase kinase 2
, rab8-interacting protein
, mitogen-activated protein kinase kinase kinase kinase 2
, mitogen-activated protein kinase kinase kinase kinase 2-like
, mitogen-activated protein kinase kinase kinase kinase 3-like