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The protein encoded by MAP4K4 is a member of the serine/threonine protein kinase family. Additionally we are shipping MAP4K4 Antibodies (149) and MAP4K4 Kits (1) and many more products for this protein.
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loss of MAP4K4 function suppressed pathological angiogenesis in disease models, identifying MAP4K4 as a potential therapeutic target
that MAP4K4, a known mediator of inflammation, is involved in KS aetiology by regulating KSHV lytic reactivation
results reveal a key target of SOX2 (show SOX2 Proteins) expression and highlight the unexpected context-dependent role for MAP4K4, a pluripotent activator of several mitogen-activated protein kinase (show MAPK1 Proteins) pathways, in regulating tumor cell survival.
TRAF1.NIK is a central complex linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex
Common polymorphisms in MAP4K4 are associated with insulin (show INS Proteins) resistance and beta-cell dysfunction, possibly via this gene's role in inflammatory signaling.
Elevated MAP4K4 expression is closely associated with lung adenocarcinoma progression with independent prognostic value in predicting overall survival for patients with lung adenocarcinoma.
MAP4K4 overexpression is an independent predictor of poor prognosis of Hepatocellular Carcinoma patients, and inhibition of its expression might be of therapeutic significance
Data show that down-regulation of hepatocyte progenitor kinase-like kinase (HGK) can obviously inhibit the migration and invasion of HepG2 cells in vitro, and suggest that HGK may be a new therapeutic target for treatment of hepatocellular carcinoma.
interaction with GBP3 (show GBP3 Proteins)
The STE20 kinase (show SLK Proteins) HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion.
These results reveal that MAP4K4 is a key signalling node that promotes immune cell recruitment in atherosclerosis.
Mice with Map4k4 deleted in Myf5 (show MYF5 Proteins)-positive tissues, including all skeletal muscles tested, were protected from obesity-induced glucose intolerance and insulin (show INS Proteins) resistance.
HGK/MAP4K4 deficiency has a role in inducing TRAF2 (show TRAF2 Proteins) stabilization and Th17 differentiation leading to insulin (show INS Proteins) resistance
microtubules can deliver MAP4K4 toward focal adhesions through ending binding 2
MAP4K4 is essential for CD4 (show CD4 Proteins)+ T cell proliferation and activation in vitro through suppressing PKC-theta (show PRKCQ Proteins) activation.
Map4k4 inhibits adipose lipogenesis by suppression of Srebp-1 (show SREBF1 Proteins) in an AMPK (show PRKAA1 Proteins)- and mTOR (show FRAP1 Proteins)-dependent but JNK (show MAPK8 Proteins)-independent mechanism.
Expression of a Map4k4 kinase-inactive mutant enhances myotube formation, suggesting that the kinase activity of Map4k4 is essential for its inhibition of muscle differentiation.
MicroRNA-30d induces insulin (show INS Proteins) transcription factor MafA (show MAFA Proteins) and insulin (show INS Proteins) production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic beta-cells.
These findings suggest that scorpion venom induces insulin (show INS Proteins) resistance by mechanisms involving TNF-alpha (show TNF Proteins)-dependent Map4k4 kinase activation in the adipose tissue.
These data together with previous reports on extramedullary hemopoiesis in RelB (show RELB Proteins)-deficient mice suggest that NIK-RelB (show RELB Proteins) signaling may be involved in the suppression of extramedullary hemopoiesis in adult mice.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
HPK/GCK-like kinase HGK
, MAPK/ERK kinase kinase kinase 4
, MEK kinase kinase 4
, Ste20 group protein kinase HGK
, hepatocyte progenitor kinase-like/germinal center kinase-like kinase
, nck-interacting kinase
, MEKKK 4
, NCK interacting kinase
, mitogen activated protein kinase kinase kinase kinase 4