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Mitogen-Activated Protein Kinase Kinase Kinase MLT Proteins (ZAK)

ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). Additionally we are shipping ZAK Antibodies (87) and ZAK Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ZAK ZAK 311743  
ZAK 51776 Q9NYL2
ZAK 65964 Q9ESL4
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Top ZAK Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

ZAK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

More Proteins for Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) interaction partners

  1. ZAK is a key player in mammalian limb patterning in humans and mice.

  2. ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers.

  3. The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK (show MAPK1 Proteins) pathway.

  4. we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun (show JUN Proteins)-NH(2)-kinase (JNK (show MAPK8 Proteins)) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK)

  5. MRK (show ICK Proteins) is a novel RhoC (show RHOC Proteins) effector that controls LPA (show APOA Proteins)-stimulated cell invasion at least in part by regulating myosin dynamics, ERK (show EPHB2 Proteins) and p38 (show CRK Proteins)

  6. The genes identified KTN1 (show KTN1 Proteins), ROCK1 (show ROCK1 Proteins), and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone

  7. decrease of lung cancer cell proliferation by ZAK may involve the ERK (show EPHB2 Proteins) and JNK (show MAPK8 Proteins) pathways via an AP-1 (show FOSB Proteins) transcription factor.

  8. In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1 (show RPS6KA5 Proteins), and show that MRK (show ICK Proteins)-beta could also activate MSK1 (show RPS6KA5 Proteins) through direct interaction.

  9. Results suggest that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F (show E2F1 Proteins) expression.

  10. Data show that in response to radiation, MRK (show ICK Proteins) controls two independent pathways: the Chk2 (show CHEK2 Proteins)-Cdc25A (show CDC25A Proteins) pathway leading to cell cycle arrest and the p38gamma (show MAPK12 Proteins) MAPK (show MAPK1 Proteins) pathway

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) interaction partners

  1. ZAK is a key player in mammalian limb patterning in humans and mice.

  2. Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6 (show ITGA6 Proteins), Zak, Gpr155, and Mtx2 (show MTX2 Proteins)) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.

  3. PKNalpha (show PKN1 Proteins) functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein (show HOMER1 Proteins) for the p38gamma (show MAPK12 Proteins) MAPK (show MAPK1 Proteins) signaling pathway

  4. Results show that mixed lineage kinase-like mitogen-activated protein triple kinase (MLTK_-alpha plays a key role in the UVB- and EGF (show EGF Proteins)-induced phosphorylation of histone H3 (show HIST3H3 Proteins) at Ser28.

  5. Mixed lineage kinase (show MAP3K12 Proteins) 7 (MLK7), a splice variant of the human ZAK gene (ortholog of mouse B230120H23Rik), encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation.

ZAK Protein Profile

Protein Summary

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with ZAK

  • sterile alpha motif and leucine zipper containing kinase AZK (Zak)
  • sterile alpha motif and leucine zipper containing kinase AZK (ZAK)
  • AV006891 protein
  • AZK protein
  • B230120H23Rik protein
  • MLK7 protein
  • mlklak protein
  • MLT protein
  • MLTK protein
  • MLTKalpha protein
  • MLTKbeta protein
  • MRK protein
  • pk protein
  • RGD1561394 protein

Protein level used designations for ZAK

mitogen-activated protein kinase kinase kinase MLT , HCCS-4 , MLK-like mitogen-activated protein triple kinase , human cervical cancer suppressor gene 4 protein , mixed lineage kinase 7 , mixed lineage kinase with a leucine zipper and a sterile alpha motif , mixed lineage kinase-related kinase MRK-beta , MLK-related kinase , MRK , leucine zipper- and sterile alpha motif kinase ZAK , mixed lineage kinase-related kinase , sterile alpha motif- and leucine zipper-containing kinase AZK , sterile-alpha motif and leucine zipper containing kinase AZK

GENE ID SPECIES
311743 Rattus norvegicus
51776 Homo sapiens
65964 Mus musculus
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