Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Proteins (MAP4K4)

The protein encoded by MAP4K4 is a member of the serine/threonine protein kinase family. Additionally we are shipping MAP4K4 Antibodies (157) and MAP4K4 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MAP4K4 9448 O95819
MAP4K4 26921 P97820
Rat MAP4K4 MAP4K4 301363  
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Top MAP4K4 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
Insect Cells Human GST tag   10 μg Log in to see 3 to 4 Days
$310.00
Details

MAP4K4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

  1. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.

  2. of the five variants, SNP rs2236935T/C was significantly associated with type 2 diabetes mellitus (T2DM) in this study population; conclude that MAP4K4 gene is associated with T2DM in a Chinese Han population, and MAP4K4 gene variants may contribute to the risk toward the development of T2DM

  3. Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D.

  4. MAP4K4 promotes the epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma cells

  5. miR (show MLXIP Proteins)-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4

  6. The results of the present study suggested that inhibition of MAP4K4 may be a therapeutic strategy for gastric cancer.

  7. loss of MAP4K4 function suppressed pathological angiogenesis in disease models, identifying MAP4K4 as a potential therapeutic target

  8. that MAP4K4, a known mediator of inflammation, is involved in KS aetiology by regulating KSHV lytic reactivation

  9. results reveal a key target of SOX2 (show SOX2 Proteins) expression and highlight the unexpected context-dependent role for MAP4K4, a pluripotent activator of several mitogen-activated protein kinase (show MAPK1 Proteins) pathways, in regulating tumor cell survival.

  10. TRAF1.NIK is a central complex linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

  1. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.

  2. These results demonstrate that protein kinase (show CDK7 Proteins) Map4k4 drives obesity-induced hyperinsulinemia and insulin (show INS Proteins) resistance in part by promoting insulin (show INS Proteins) secretion from beta cells in mice.

  3. These results reveal that MAP4K4 is a key signalling node that promotes immune cell recruitment in atherosclerosis.

  4. Mice with Map4k4 deleted in Myf5 (show MYF5 Proteins)-positive tissues, including all skeletal muscles tested, were protected from obesity-induced glucose intolerance and insulin (show INS Proteins) resistance.

  5. HGK/MAP4K4 deficiency has a role in inducing TRAF2 (show TRAF2 Proteins) stabilization and Th17 differentiation leading to insulin (show INS Proteins) resistance

  6. microtubules can deliver MAP4K4 toward focal adhesions through ending binding 2

  7. MAP4K4 is essential for CD4 (show CD4 Proteins)+ T cell proliferation and activation in vitro through suppressing PKC-theta (show PRKCQ Proteins) activation.

  8. Map4k4 inhibits adipose lipogenesis by suppression of Srebp-1 (show SREBF1 Proteins) in an AMPK (show PRKAA1 Proteins)- and mTOR (show FRAP1 Proteins)-dependent but JNK (show MAPK8 Proteins)-independent mechanism.

  9. Expression of a Map4k4 kinase-inactive mutant enhances myotube formation, suggesting that the kinase activity of Map4k4 is essential for its inhibition of muscle differentiation.

  10. MicroRNA-30d induces insulin (show INS Proteins) transcription factor MafA (show MAFA Proteins) and insulin (show INS Proteins) production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic beta-cells.

Cow (Bovine) Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

  1. study identified single nucleotide polymorphisms at different locations of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) gene of cattle and several of them were significantly associated with the somatic cell score and other different milk traits

MAP4K4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with MAP4K4

  • mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
  • mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4)
  • 9430080K19Rik protein
  • AU043147 protein
  • AU045934 protein
  • AW046177 protein
  • FLH21957 protein
  • HGK protein
  • MEKKK4 protein
  • Nik protein

Protein level used designations for MAP4K4

HPK/GCK-like kinase HGK , MAPK/ERK kinase kinase kinase 4 , MEK kinase kinase 4 , Ste20 group protein kinase HGK , hepatocyte progenitor kinase-like/germinal center kinase-like kinase , nck-interacting kinase , MEKKK 4 , NCK interacting kinase , mitogen activated protein kinase kinase kinase kinase 4

GENE ID SPECIES
9448 Homo sapiens
26921 Mus musculus
418714 Gallus gallus
100516547 Sus scrofa
509109 Bos taurus
301363 Rattus norvegicus
481331 Canis lupus familiaris
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