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Activates the JUN N-terminal pathway (By similarity).. Additionally we are shipping Mitogen-Activated Protein Kinase Kinase Kinase MLK4 Antibodies (65) and many more products for this protein.
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MLK4 is a negative regulator of TLR4 (show TLR4 Proteins) signaling.
results uncover MLK4 as an upstream regulator of NF-kappaB (show NFKB1 Proteins) signaling and a potential molecular target for the MES (show ME1 Proteins) subtype of glioblastomas
In establishing the role of MLK4 in intracellular signaling, we show it directly phosphorylates MEK1 (MAP2K1 (show MAP2K1 Proteins)) and that MEK (show MAP2K1 Proteins)/ERK (MAPK1 (show MAPK1 Proteins)) signaling is impaired in MLK4 knockout cells
Activates the JUN N-terminal pathway (By similarity).
mitogen-activated protein kinase kinase kinase MLK4
, mixed lineage kinase 4