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MGLL encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. Additionally we are shipping MGLL Antibodies (127) and MGLL Proteins (13) and many more products for this protein.
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Monoacylglycerol lipase sulfenylation might act as an intrinsic neuroprotective mechanism by potentiating 2-AG signaling at CB1 (show CNR1 ELISA Kits) receptors.
The study identified monoacylglycerol lipase as a YAP (show YAP1 ELISA Kits) transcriptional target and an inhibitor of anchorage-dependent cell growth.
Molecular dynamics and nudged elastic band simulations were used to explore the conformational transition pathway of the helix alpha4 of human monoacylglycerol lipase.
role of monoacylglycerol lipase (MAGL) in the cancer progress
Our findings establish that MAGL promotes metastases in nasopharyngeal carcinoma
In subcutaneous adipose tissue, DAGL-a mRNA was upregulated and fatty acid amide hydrolase (FAAH (show FAAH ELISA Kits)) and monoacylglycerol lipase (MAGL) mRNAs were down-regulated in obese subjects, but the diets had no influence.
In obese humans, FAAH (show FAAH ELISA Kits) or MGL (show CLEC10A ELISA Kits) activity in adipocytes is not affected by diabetes, dyslipidaemia or other markers of metabolic dysfunction.
Mutation of Cys242 was also found to impair inhibition of monoacylglycerol lipase.
MGL (show CLEC10A ELISA Kits) interaction with a phospholipid membrane bilayer induces regional changes in the enzyme's conformation that favor its recruiting lipophilic substrate from membrane stores to the active site resulting in enhanced MGL (show CLEC10A ELISA Kits) catalytic activity.
Data indicate that N,N-dimethyl-5-(4-phenoxyphenyl)-2H-tetrazole-2-carboxamide inhibited monoacylglycerol lipase (MAGL) with IC50 0.028 muM.
MGL (show CLEC10A ELISA Kits) in astrocytes is an important regulator of 2-arachidonoylglyerol levels, arachidonic acid availability, and neuroinflammation.
Genetic and pharmacological ablation of Magl attenuated centrally-mediated fever response.
the results indicate that global MGL (show CLEC10A ELISA Kits) deletion leads to systemic changes that produce a leaner (show CACNA1A ELISA Kits) phenotype and an improved serum metabolic profile.
This study showed that Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CBR (show CBR1 ELISA Kits) signaling and anxiety-like behavior.
Suggest that organophosphate agents induce plasma hypertriglyceridemia in mouse through single or dual inhibition of FAAH (show FAAH ELISA Kits) or/and MAGL, apparently leading to overstimulation of cannabinoid signal regulating energy metabolism.
Inactivation of Monoacylglycerol lipase robustly suppressed production and accumulation of beta-amyloid (Abeta (show APP ELISA Kits)) associated with reduced expression of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1 (show BACE ELISA Kits)) in a mouse model of Alzheimer's disease.
Data indicate that nerve growth factor (NGF) controls monoacylglycerol lipase (MGL) degradation in vitro and in vivo.
The results therefore suggest a role for intestinal MGL (show CLEC10A ELISA Kits) in whole body energy balance via regulation of food intake as well as metabolic rate.
MGL (show CLEC10A ELISA Kits) regulates 2-arachidonoylglycerol signaling rather broadly within a certain range of neural tissue, although MGL (show CLEC10A ELISA Kits) expression is heterogeneous and limited to a subset of nerve terminals and astrocytes.
results indicate that genetic deletion of MAGL causes profound changes in eCB signaling, long-term synaptic plasticity, and learning behavior.
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, Monoglyceride lipase
, lysophospholipase homolog
, monoacylglycerol lipase