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MUC2 encodes a member of the mucin protein family. Additionally we are shipping MUC2 Kits (42) and MUC2 Proteins (11) and many more products for this protein.
Showing 10 out of 133 products:
Human Monoclonal MUC2 Primary Antibody for IHC, ELISA - ABIN966605
Chang, Dohrman, Basbaum, Ho, Tsuda, Toribara, Gum, Kim: Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. in Gastroenterology 1994
Show all 5 references for ABIN966605
Human Polyclonal MUC2 Primary Antibody for IHC (fro), IF - ABIN1449424
Gum, Byrd, Hicks, Toribara, Lamport, Kim: Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. in The Journal of biological chemistry 1989
Show all 3 references for ABIN1449424
Human Monoclonal MUC2 Primary Antibody for FACS, IHC (fro) - ABIN181865
Durrant, Jacobs, Price: Production of monoclonal antibodies recognising the peptide core of MUC2 intestinal mucin. in European journal of cancer (Oxford, England : 1990) 1994
Human Monoclonal MUC2 Primary Antibody for IHC (fro), IF - ABIN126021
Xing, Prenzoska, Layton, Devine, McKenzie: Second-generation monoclonal antibodies to intestinal MUC2 peptide reactive with colon cancer. in Journal of the National Cancer Institute 1992
This triggers calcium ion-dependent compound exocytosis of Muc2 mucin (show SLC13A2 Antibodies) from the senGC and generates an intercellular gap junction signal; in turn, this signal induces Muc2 secretion from adjacent goblet cells in the upper crypt, which expels bacteria.
HIF-1alpha (show HIF1A Antibodies) inhibition decreases MUC2 production and mucinous tumor growth, providing a preclinical rationale for the use of HIF-1alpha (show HIF1A Antibodies) inhibitors to treat patients with PMP
colitic Muc2-/- mice have reduced colon CD103 (show ITGAE Antibodies)+ CD11b (show ITGAM Antibodies)- dendritic cells and increased CD103 (show ITGAE Antibodies)- CD11b (show ITGAM Antibodies)+ phagocytes.
expression of MUC2 mRNA is found to be more expressed in Eimeria infected females than males
MUC2 silencing increases interleukin (IL)-6 (show IL6 Antibodies) secretion by colon cancer cells.
These results suggest that SAA3 plays a role in host innate immunity in the colon by up-regulating MUC2 mucin (show SLC13A2 Antibodies) production, which builds a physiological barrier of colonic epithelia against bacterial invasion.
Alterations in the immune compartment due to intestinal bacterial breach in Muc2-/- mice, were investigated.
Meprin beta (show MEP1B Antibodies) is an endogenous zinc-dependent metalloprotease (show ADAMTS7 Antibodies) now shown to cleave the N-terminal region of the MUC2 mucin (show SLC13A2 Antibodies) at two specific sites.
These data suggest that the intestinal mucus layer (Muc2) and core 3 O-glycosylation play critical roles in controlling Salmonella intestinal burdens and intestinal epithelial barrier function, respectively.
Report regiospecific Muc2 O-glycan patterns in mouse stomach, small intestines and colon.
Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1
Our results unraveled an important regulatory role for MUC2 mucin (show SLC13A2 Antibodies) in human beta-defensin2 mRNA and peptide production in a proinflammatory milieu
There was no significant difference in MUC2 expression between chronic rhinosinusitis patients with and without bacterial biofilm formation.
In ovarian mucinous tumors, MUC2 expression changes with the progression of benign to borderline and malignant tumours
The genetic length variants in the central repetitive region of MUC2 were not associated with meconium ileus in cystic fibrosis (show S100A8 Antibodies).
The expression of a subset of mucins (MUC2, MUC6 (show MUC6 Antibodies), MUC5B (show MUC5B Antibodies)) was also correlated with sialyl-Tn expression in LS174T cells.
There was no difference in the expression of deep MUC1 (show MUC1 Antibodies), MUC2, MUC5AC, or MUC6 (show MUC6 Antibodies) between the groups of gastric cancer and controls.
The results indicated that the DNA methylation (show HELLS Antibodies) status of MUC1 (show MUC1 Antibodies), MUC2 and MUC4 (show MUC4 Antibodies) in pancreatic juice matched with the mucin (show SLC13A2 Antibodies) expression in tissue.
Expression of Hath1 (show ATOH1 Antibodies), Muc2, cyclin D1 (show CCND1 Antibodies) and p27 (show PAK2 Antibodies) in the xenograft tumors was also detected.
Down-regulated expression of MUC-2, -4 and -5AC may be involved in pathogenesis.
identified a specific depletion of secreted MUC2 from goblet cells in Lawsonia intracellularis-infected pigs that correlated with the increased level of intracellular bacteria in crypt cells
The structures of purified soluble porcine gastric (Muc5ac) and duodenal (Muc2) mucin (show SLC13A2 Antibodies) solutions at neutral and acidic pH were examined using small-angle X-ray scattering and small-angle neutron scattering experiments
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
, secreted gel-forming mucin
, intestinal mucin-2
, mucin 2, intestinal/tracheal
, mucin-like protein