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MUC2 encodes a member of the mucin protein family. Additionally we are shipping MUC2 Kits (50) and MUC2 Proteins (17) and many more products for this protein.
Showing 10 out of 232 products:
Human Monoclonal MUC2 Primary Antibody for IHC, ELISA - ABIN966605
Chang, Dohrman, Basbaum, Ho, Tsuda, Toribara, Gum, Kim: Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. in Gastroenterology 1994
Show all 5 references for 966605
Human Polyclonal MUC2 Primary Antibody for IHC (fro), IF - ABIN1449424
Gum, Byrd, Hicks, Toribara, Lamport, Kim: Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. in The Journal of biological chemistry 1989
Show all 3 references for 1449424
Human Monoclonal MUC2 Primary Antibody for IHC (p), WB - ABIN180497
Xing, Prenzoska, Layton, Devine, McKenzie: Second-generation monoclonal antibodies to intestinal MUC2 peptide reactive with colon cancer. in Journal of the National Cancer Institute 1992
Human Polyclonal MUC2 Primary Antibody for ICC, IF - ABIN441262
Kameoka, Kitazawa, Ariasu, Tachibana, Mizuno, Haraguchi, Kitazawa: Reactivation of CDX2 in Gastric Cancer as Mark for Gene Silencing Memory. in Acta histochemica et cytochemica 2015
Human Monoclonal MUC2 Primary Antibody for FACS, IHC (fro) - ABIN265845
Mishra, Verma, Alpini, Meng, Kumar: Role of Janus kinase 3 in mucosal differentiation and predisposition to colitis. in The Journal of biological chemistry 2013
Human Monoclonal MUC2 Primary Antibody for FACS, ICC - ABIN4336463
Salerno-Goncalves, Safavie, Fasano, Sztein: Free and complexed-secretory immunoglobulin A triggers distinct intestinal epithelial cell responses. in Clinical and experimental immunology 2016
Human Monoclonal MUC2 Primary Antibody for FACS, IHC (fro) - ABIN181865
Durrant, Jacobs, Price: Production of monoclonal antibodies recognising the peptide core of MUC2 intestinal mucin. in European journal of cancer (Oxford, England : 1990) 1994
These studies demonstrate regulatory mechanisms between MUC2 and cathelicidins in the colonic mucosa where an intact mucus barrier is essential for expression and secretion of cathelicidins in response to E. histolytica- and DSS (show PMP22 Antibodies)-induced colitis.
the intestinal specificity of mucin 2 (MUC2) expression was identified in mice and humans, and further confirmed in chickens.
This triggers calcium ion-dependent compound exocytosis of Muc2 mucin (show SLC13A2 Antibodies) from the senGC and generates an intercellular gap junction signal; in turn, this signal induces Muc2 secretion from adjacent goblet cells in the upper crypt, which expels bacteria.
HIF-1alpha (show HIF1A Antibodies) inhibition decreases MUC2 production and mucinous tumor growth, providing a preclinical rationale for the use of HIF-1alpha (show HIF1A Antibodies) inhibitors to treat patients with PMP
colitic Muc2-/- mice have reduced colon CD103 (show ITGAE Antibodies)+ CD11b (show ITGAM Antibodies)- dendritic cells and increased CD103 (show ITGAE Antibodies)- CD11b (show ITGAM Antibodies)+ phagocytes.
expression of MUC2 mRNA is found to be more expressed in Eimeria infected females than males
MUC2 silencing increases interleukin (IL)-6 (show IL6 Antibodies) secretion by colon cancer cells.
These results suggest that SAA3 plays a role in host innate immunity in the colon by up-regulating MUC2 mucin (show SLC13A2 Antibodies) production, which builds a physiological barrier of colonic epithelia against bacterial invasion.
Alterations in the immune compartment due to intestinal bacterial breach in Muc2-/- mice, were investigated.
Meprin beta (show MEP1B Antibodies) is an endogenous zinc-dependent metalloprotease (show ADAMTS7 Antibodies) now shown to cleave the N-terminal region of the MUC2 mucin (show SLC13A2 Antibodies) at two specific sites.
Among the mild and moderate/severe intestinal metaplasia of gastric mucosa specimens, the relative expression levels of MUC2, a gastrointestinal differentiation marker, were elevated by approximately 6.2- and 21.4-fold
loss of MUC2 expression proved to be a predictor of adverse outcome, while the gain of aberrant expression of MUC5AC and particularly of MUC6 (show MUC6 Antibodies) was associated with favorable outcome in colorectal cancer, notably in intermediate stages II and III
This shows for the first time that transamidation is not only stabilizing the skin and the fibrin clot (show TXNDC17 Antibodies), but is also important for the correct intracellular processing of MUC2 to generate protective mucus.
Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1
Our results unraveled an important regulatory role for MUC2 mucin (show SLC13A2 Antibodies) in human beta-defensin2 mRNA and peptide production in a proinflammatory milieu
There was no significant difference in MUC2 expression between chronic rhinosinusitis patients with and without bacterial biofilm formation.
In ovarian mucinous tumors, MUC2 expression changes with the progression of benign to borderline and malignant tumours
The genetic length variants in the central repetitive region of MUC2 were not associated with meconium ileus in cystic fibrosis (show S100A8 Antibodies).
The expression of a subset of mucins (MUC2, MUC6 (show MUC6 Antibodies), MUC5B (show MUC5B Antibodies)) was also correlated with sialyl-Tn expression in LS174T cells.
identified a specific depletion of secreted MUC2 from goblet cells in Lawsonia intracellularis-infected pigs that correlated with the increased level of intracellular bacteria in crypt cells
The structures of purified soluble porcine gastric (Muc5ac) and duodenal (Muc2) mucin (show SLC13A2 Antibodies) solutions at neutral and acidic pH were examined using small-angle X-ray scattering and small-angle neutron scattering experiments
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
, secreted gel-forming mucin
, intestinal mucin-2
, mucin 2, intestinal/tracheal
, mucin-like protein