Mucin 2, Oligomeric Mucus/gel-Forming Proteins (MUC2)

MUC2 encodes a member of the mucin protein family. Additionally we are shipping MUC2 Antibodies (238) and MUC2 Kits (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MUC2 17831  
MUC2 4583 Q02817
Rat MUC2 MUC2 24572  
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Top MUC2 Proteins at antibodies-online.com

Showing 7 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$723.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
Details
Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$640.00
Details
HOST_Wild boar Wild boar Un-conjugated   100 μg Log in to see 15 to 18 Days
$672.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$845.63
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$873.13
Details

MUC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Mucin 2, Oligomeric Mucus/gel-Forming (MUC2) Interaction Partners

Mouse (Murine) Mucin 2, Oligomeric Mucus/gel-Forming (MUC2) interaction partners

  1. The major responsible region for MUC2 expression exists in amino acids 1-36 of SAA3 (show SAA3 Proteins).

  2. loss of KLF4 (show KLF4 Proteins) and expression of MUC2 could be important markers for gastric cancer diagnosis.

  3. These studies demonstrate regulatory mechanisms between MUC2 and cathelicidins in the colonic mucosa where an intact mucus barrier is essential for expression and secretion of cathelicidins in response to E. histolytica- and DSS (show PMP22 Proteins)-induced colitis.

  4. the intestinal specificity of mucin 2 (MUC2) expression was identified in mice and humans, and further confirmed in chickens.

  5. This triggers calcium ion-dependent compound exocytosis of Muc2 mucin (show SLC13A2 Proteins) from the senGC and generates an intercellular gap junction signal; in turn, this signal induces Muc2 secretion from adjacent goblet cells in the upper crypt, which expels bacteria.

  6. HIF-1alpha (show HIF1A Proteins) inhibition decreases MUC2 production and mucinous tumor growth, providing a preclinical rationale for the use of HIF-1alpha (show HIF1A Proteins) inhibitors to treat patients with PMP

  7. colitic Muc2-/- mice have reduced colon CD103 (show ITGAE Proteins)+ CD11b (show ITGAM Proteins)- dendritic cells and increased CD103 (show ITGAE Proteins)- CD11b (show ITGAM Proteins)+ phagocytes.

  8. expression of MUC2 mRNA is found to be more expressed in Eimeria infected females than males

  9. MUC2 silencing increases interleukin (IL)-6 (show IL6 Proteins) secretion by colon cancer cells.

  10. These results suggest that SAA3 (show SAA3 Proteins) plays a role in host innate immunity in the colon by up-regulating MUC2 mucin (show SLC13A2 Proteins) production, which builds a physiological barrier of colonic epithelia against bacterial invasion.

Human Mucin 2, Oligomeric Mucus/gel-Forming (MUC2) interaction partners

  1. loss of KLF4 (show KLF4 Proteins) and expression of MUC2 could be important markers for gastric cancer diagnosis.

  2. Our association of MUC2 in the Dutch ulcerative colitis population could not be replicated in a German cohort, this might be because our associated SNVs are population specific or because of a lack of power.

  3. Among the mild and moderate/severe intestinal metaplasia of gastric mucosa specimens, the relative expression levels of MUC2, a gastrointestinal differentiation marker, were elevated by approximately 6.2- and 21.4-fold

  4. the intestinal specificity of mucin 2 (MUC2) expression was identified in mice and humans, and further confirmed in chickens.

  5. loss of MUC2 expression proved to be a predictor of adverse outcome, while the gain of aberrant expression of MUC5AC and particularly of MUC6 (show MUC6 Proteins) was associated with favorable outcome in colorectal cancer, notably in intermediate stages II and III

  6. This shows for the first time that transamidation is not only stabilizing the skin and the fibrin clot (show TXNDC17 Proteins), but is also important for the correct intracellular processing of MUC2 to generate protective mucus.

  7. Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1

  8. Our results unraveled an important regulatory role for MUC2 mucin (show SLC13A2 Proteins) in human beta-defensin2 mRNA and peptide production in a proinflammatory milieu

  9. There was no significant difference in MUC2 expression between chronic rhinosinusitis patients with and without bacterial biofilm formation.

  10. In ovarian mucinous tumors, MUC2 expression changes with the progression of benign to borderline and malignant tumours

Pig (Porcine) Mucin 2, Oligomeric Mucus/gel-Forming (MUC2) interaction partners

  1. identified a specific depletion of secreted MUC2 from goblet cells in Lawsonia intracellularis-infected pigs that correlated with the increased level of intracellular bacteria in crypt cells

  2. The structures of purified soluble porcine gastric (Muc5ac) and duodenal (Muc2) mucin (show SLC13A2 Proteins) solutions at neutral and acidic pH were examined using small-angle X-ray scattering and small-angle neutron scattering experiments

MUC2 Protein Profile

Protein Summary

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with MUC2

  • mucin 2 (Muc2)
  • mucin 2 (MUC2)
  • mucin 2, oligomeric mucus/gel-forming (MUC2)
  • mucin 2, oligomeric mucus/gel-forming (Muc2)
  • small intestinal mucin (LOC100127145)
  • 2010015E03Rik protein
  • HH-Muc protein
  • MCM protein
  • MLP protein
  • MUC-2 protein
  • SMUC protein
  • wnn protein

Protein level used designations for MUC2

colonic mucin , mucin-2 , secreted gel-forming mucin , intestinal mucin-2 , mucin 2, intestinal/tracheal , mucin-like protein , MUC-2

GENE ID SPECIES
17831 Mus musculus
789571 Bos taurus
100724045 Cavia porcellus
4583 Homo sapiens
24572 Rattus norvegicus
423101 Gallus gallus
100127145 Sus scrofa
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