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The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. Additionally we are shipping MUC4 Kits (30) and MUC4 Proteins (6) and many more products for this protein.
Showing 10 out of 87 products:
Human Monoclonal MUC4 Primary Antibody for IHC (p), ELISA - ABIN561876
Smalley, Sheman, Nelson, Theodorescu: Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. in Journal of proteome research 2008
Show all 4 references for ABIN561876
Human Monoclonal MUC4 Primary Antibody for BCA - ABIN2664001
Chaturvedi, Singh, Batra: Structure, evolution, and biology of the MUC4 mucin. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Show all 3 references for ABIN2664001
Results show that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin (show SLC13A2 Antibodies) in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients.
Using the Pdx1-Cre; LStopL-K-rasG12D mouse model of pancreatic carcinogenesis, in vivo early Muc4 neo-expression of in pancreatic intraepithelial neoplastic lesio (show JUN Antibodies)ns ind (show MAPK1 Antibodies)uced (show MAPK8 Antibodies)by mutated hK- (show NFKB1 Antibodies)ras is correlated with the ERK, JNK and NF-kappaB sign (show Ralb Antibodies)aling p (show RACGAP1 Antibodies)athways.
Data show that Muc4 is upregulated and interacts with erbB2 (show ERBB2 Antibodies) in gallbladders from BK5.erbB2 (show ERBB2 Antibodies) mice suggesting its important role during gallbladder carcinogenesis and/or cancer growth by potentiating erbB2 (show ERBB2 Antibodies) signaling.
This study delineates the association and the downstream mechanisms of MUC4-regulated elevation of lipocalin-2 (show LCN2 Antibodies) and its clinical significance for prognosis of pancreatic cancer.
MUC4-NIDO domain significantly contributes to the MUC4-mediated metastasis of PC cells
ErbB2 (show ERBB2 Antibodies) and MUC4, which interact physically, activate different intracellular signalling pathways to regulate biological properties of CAPAN-2 pancreatic cancer cells
As a luminal surface component, the MUC4 is situated to contribute to the non-adhesive luminal surface and to act as an intrinsic protection and survival factor for blood vessels
MUC4 is regulated at the transcriptional level by CDX-1 (show CDX1 Antibodies) and -2, HNF-1 alpha (show HNF1A Antibodies) and -1 beta, FOXA1 (show FOXA1 Antibodies)/A2, HNF-4 alpha (show HNF4A Antibodies) and -4 gamma, and GATA-4 (show GATA4 Antibodies), -5, and -6 factors in a cell-specific manner
the expression of mucins 1 to 4 and trefoil factor 3 (show TFF3 Antibodies) was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free animals
Butyrate enemas upregulate Muc4 gene expression but decrease adherent mucus thickness in mice colon.
High MUC4 expression is associated with colorectal cancer cell migration and invasion.
authors show for the first time that beta-catenin (show CTNNB1 Antibodies) directly governs MUC4 in pancreatic cancer.
High MUC4 expression is associated wit response to chemotherapy in esophageal squamous cell carcinoma.
The most highly up-regulated gene was mucin 4 (MUC4), and its protein product was confirmed to be over-expressed in periodontitis
MUC4 has a role in promoting neural invasion mediated by the axon guidance factor Netrin-1 (show NTN1 Antibodies) in pancreatic ductal adenocarcinoma
HER3 (show ERBB3 Antibodies)/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
repressing MUC4 transcription, inhibiting post-transcriptional regulation, including alternative splicing, or blocking various pathways simultaneously may be helpful for controlling malignant progression
Transfection of constitutively activated K-rasG12V in pancreatic cancer cells led to the transcriptional upregulation of MUC4 at the transcriptional level by AP-1 (show FOSB Antibodies), MAPK (show MAPK1 Antibodies), JNK (show MAPK8 Antibodies) and NF-kappaB (show NFKB1 Antibodies) pathways and at the posttranscriptional level by RalB (show Ralb Antibodies) GTPase (show RACGAP1 Antibodies).
This epigenome-wide DNA methylation (show HELLS Antibodies) analysis in postmortem hippocampus and prefrontal cortex specimens confirmed MUC4 DNA methylation (show HELLS Antibodies) profiles in major depression.
Polymorphism of FUT1 (show FUT1 Antibodies) and MUC4 associated with resistance to colibacteriosis was determined.
Haplotype phylogeny analyses indicated that MUC4 had evolved divergently in Chinese and Western pigs.
A SNP in exon 7 of the mucin 4 (MUC4) gene (DQ848681:g.8227C>G), shown to be in close linkage disequilibrium with the F4bcR locus, has been used as marker to identify ETEC susceptible pigs.
data suggest that MUC4 could play an important role in the establishment of an optimal uterine environment that would increase embryonic survival during pig gestation
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
, mucin 4, ASGP
, pancreatic adenocarcinoma mucin
, testis mucin
, mucin 4, tracheobronchial
, tracheobronchial mucin
, pre-sialomucin complex
, sialomucin ascites sialoglycoprotein-1
, sialomucin complex