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Mucin 4, Cell Surface Associated Proteins (MUC4)

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. Additionally we are shipping MUC4 Antibodies (55) and MUC4 Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MUC4 140474  
MUC4 4585 Q99102
Rat MUC4 MUC4 303887  
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Top MUC4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details

MUC4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Mucin 4, Cell Surface Associated (MUC4) Interaction Partners

Mouse (Murine) Mucin 4, Cell Surface Associated (MUC4) interaction partners

  1. Results show that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin (show SLC13A2 Proteins) in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients.

  2. Using the Pdx1-Cre; LStopL-K-rasG12D mouse model of pancreatic carcinogenesis, in vivo early Muc4 neo-expression of in pancreatic intraepithelial neoplastic lesio (show JUN Proteins)ns ind (show MAPK1 Proteins)uced (show MAPK8 Proteins)by mutated hK- (show NFKB1 Proteins)ras is correlated with the ERK, JNK and NF-kappaB sign (show Ralb Proteins)aling p (show RACGAP1 Proteins)athways.

  3. Data show that Muc4 is upregulated and interacts with erbB2 (show ERBB2 Proteins) in gallbladders from BK5.erbB2 (show ERBB2 Proteins) mice suggesting its important role during gallbladder carcinogenesis and/or cancer growth by potentiating erbB2 (show ERBB2 Proteins) signaling.

  4. This study delineates the association and the downstream mechanisms of MUC4-regulated elevation of lipocalin-2 (show LCN2 Proteins) and its clinical significance for prognosis of pancreatic cancer.

  5. MUC4-NIDO domain significantly contributes to the MUC4-mediated metastasis of PC cells

  6. ErbB2 (show ERBB2 Proteins) and MUC4, which interact physically, activate different intracellular signalling pathways to regulate biological properties of CAPAN-2 pancreatic cancer cells

  7. As a luminal surface component, the MUC4 is situated to contribute to the non-adhesive luminal surface and to act as an intrinsic protection and survival factor for blood vessels

  8. MUC4 is regulated at the transcriptional level by CDX-1 (show CDX1 Proteins) and -2, HNF-1 alpha (show HNF1A Proteins) and -1 beta, FOXA1 (show FOXA1 Proteins)/A2, HNF-4 alpha (show HNF4A Proteins) and -4 gamma, and GATA-4 (show GATA4 Proteins), -5, and -6 factors in a cell-specific manner

  9. the expression of mucins 1 to 4 and trefoil factor 3 (show TFF3 Proteins) was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free animals

  10. Butyrate enemas upregulate Muc4 gene expression but decrease adherent mucus thickness in mice colon.

Human Mucin 4, Cell Surface Associated (MUC4) interaction partners

  1. authors show for the first time that beta-catenin (show CTNNB1 Proteins) directly governs MUC4 in pancreatic cancer.

  2. High MUC4 expression is associated wit response to chemotherapy in esophageal squamous cell carcinoma.

  3. The most highly up-regulated gene was mucin 4 (MUC4), and its protein product was confirmed to be over-expressed in periodontitis

  4. MUC4 has a role in promoting neural invasion mediated by the axon guidance factor Netrin-1 (show NTN1 Proteins) in pancreatic ductal adenocarcinoma

  5. Results show that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin (show SLC13A2 Proteins) in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients.

  6. HER3 (show ERBB3 Proteins)/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

  7. repressing MUC4 transcription, inhibiting post-transcriptional regulation, including alternative splicing, or blocking various pathways simultaneously may be helpful for controlling malignant progression

  8. Transfection of constitutively activated K-rasG12V in pancreatic cancer cells led to the transcriptional upregulation of MUC4 at the transcriptional level by AP-1 (show FOSB Proteins), MAPK (show MAPK1 Proteins), JNK (show MAPK8 Proteins) and NF-kappaB (show NFKB1 Proteins) pathways and at the posttranscriptional level by RalB (show Ralb Proteins) GTPase (show RACGAP1 Proteins).

  9. This epigenome-wide DNA methylation (show HELLS Proteins) analysis in postmortem hippocampus and prefrontal cortex specimens confirmed MUC4 DNA methylation (show HELLS Proteins) profiles in major depression.

  10. High MUC4 expression is associated with pancreatic cancer.

Pig (Porcine) Mucin 4, Cell Surface Associated (MUC4) interaction partners

  1. Polymorphism of FUT1 (show FUT1 Proteins) and MUC4 associated with resistance to colibacteriosis was determined.

  2. Haplotype phylogeny analyses indicated that MUC4 had evolved divergently in Chinese and Western pigs.

  3. A SNP in exon 7 of the mucin 4 (MUC4) gene (DQ848681:g.8227C>G), shown to be in close linkage disequilibrium with the F4bcR locus, has been used as marker to identify ETEC susceptible pigs.

  4. data suggest that MUC4 could play an important role in the establishment of an optimal uterine environment that would increase embryonic survival during pig gestation

MUC4 Protein Profile

Protein Summary

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.

Gene names and symbols associated with MUC4

  • mucin 4 (Muc4)
  • mucin 4 (LOC100350577)
  • mucin 4, cell surface associated (MUC4)
  • mucin 4, cell surface associated (Muc4)
  • 4933405I11Rik protein
  • ASGP protein
  • ASGP-1 protein
  • HSA276359 protein
  • MUC-4 protein
  • Psmc protein

Protein level used designations for MUC4

ascites sialoglycoprotein , mucin 4, ASGP , mucin-4 , pancreatic adenocarcinoma mucin , testis mucin , mucin 4, tracheobronchial , tracheobronchial mucin , ASGP , MUC-4 , pre-sialomucin complex , sialomucin ascites sialoglycoprotein-1 , sialomucin complex

GENE ID SPECIES
140474 Mus musculus
100350577 Oryctolagus cuniculus
4585 Homo sapiens
303887 Rattus norvegicus
100157344 Sus scrofa
786701 Bos taurus
100724323 Cavia porcellus
488024 Canis lupus familiaris
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