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MUC5B encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. Additionally we are shipping MUC5B Antibodies (132) and MUC5B Kits (43) and many more products for this protein.
Showing 8 out of 11 products:
Mucins and AQP5 gene expression were significantly higher in patients with OME relative to controls. A 2-fold increase in MUC5B correlated with increased hearing loss (air-bone gap: 7.45 dB [95% CI, 2.65-12.24 dB]; sound field: 6.66 dB [95% CI, 6.63-6.69 dB]), effusion viscosity (2.75 mL/mg; 95% CI, 0.89-4.62 mL/mg), middle ear epithelial thickness (3.5 mum; 95% CI, 1.96-5.13 mum), and neutrophil infiltration (odds rat...
This study identified rare and common variants in the MUC5B gene that are associated with type 2 diabetes in Han Chinese. These findings suggest that dysregulated MUC5B expression may be involved in the pathogenesis of type 2 diabetes.
a critical regulatory domain that contains the MUC5B promoter variant and has a highly conserved forkhead box protein A2 (FOXA2 (show FOXA2 Proteins)) binding motif, is identified.
There is no evidence of major proteolytic processing of D-domains during the production of the mature secreted polymeric mucin (show SLC13A2 Proteins) in normal and cystic fibrosis (show S100A8 Proteins) primary bronchial epithelial cells.
MUC5B was significantly more often detected in middle ear effusion fluid relative to MUC5AC. MUC5B presence was statistically associated with mucoid effusions relative to serous effusions.
Results collectively indicate unique links between dual-specificity phosphatase 28 (DUSP28) and mucins MUC5B/MUC16 and their roles in pancreatic cancer.
Study provides evidence showing that MUC5B expression in cancer cells contributes to certain tumorigenic properties of breast cancer cells, such as cell growth, adhesion, clonogenic ability and drug chemo-resistance.
this study shows that histamine activated the NF-kappaB pathway, contributing to MUC5B overproduction and secretion in nasal epithelial cells
This study showed that MUC5B minor allele predisposes to poradic idiopathic pulmonary fi brosis (spIPF), familial interstitial pneumonia (FIP) and idiopathic non-speci fi c interstitial pneumonia. In spIPF, survival is not in fl uenced by MUC5B alleles. In FIP, MUC5B minor allele predicts better survival.
MUC5B may play a role in the development of pediatric fibrotic lung disease in patients with Surfactant Protein C (show SFTPC Proteins) mutations
The decrease density of mucin-5B (Muc5b+) conjunctival goblet cell population in the dry eye syndrome (DES (show DES Proteins)) model reflects the whole conjunctival goblet cell loss, indicating Muc5b is a biological marker of DES (show DES Proteins) models.
Reduced levels of Muc5b in aged mice may be contribute to decreased mucociliary clearance.
Both compounds down regulated mucin (show SLC13A2 Proteins) 5 subtype B, and peptidoglycan recognition protein 1 (show PGLYRP1 Proteins) in vaginal tissue
Expressions of Orai1 (show TMEM132A Proteins), Muc5b, IL-4 (show IL4 Proteins), IL-5 (show IL5 Proteins), IL-13 (show IL13 Proteins) and IL-33 (show IL33 Proteins) were up-regulated in the allergic state and IL-33 (show IL33 Proteins) increased the levels of Muc5b, IL-4 (show IL4 Proteins), IL-5 (show IL5 Proteins) and IL-13 (show IL13 Proteins), but did not influence proliferation of T cells.
deleting either the Muc5ac or Muc5b gene is insufficient to create an observable dry eye phenotype on the ocular surface of these mice.
mouse Muc5b (but not Muc5ac) is required for mucociliary clearance, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc5ac is dispensable
Muc5b was detected in all mammary tumors analyzed from MMTV-ras mice
Muc5b is a target gene of transcription factors (TTF-1, GATA-6) involved in lung differentiation programs during development and carcinogenesis. TTF-1 is a strong repressor of Muc5b.
analysis of Muc5ac and Muc5b production during prenatal and postnatal murine lung development
Acidic pH drives middle ear epithelial Muc5b gene expression in vitro, which perhaps explains how laryngopharyngeal reflux can contribute to otitis media.
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.
cervical mucin MUC5B
, high molecular weight salivary mucin MG1
, mucin 5, subtype B, tracheobronchial
, sublingual gland mucin
, ovomucin, alpha-subunit
, mucin 5B, oligomeric mucus/gel-forming
, mucin protein
, mucin 5, subtype B, tracheobronchial-like