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MUC5B encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions.
Showing 10 out of 46 products:
Human Polyclonal MUC5B Primary Antibody for ICC, IF - ABIN4336716
Meyerholz, Stoltz, Namati, Ramachandran, Pezzulo, Smith, Rector, Suter, Kao, McLennan, Tearney, Zabner, McCray, Welsh: Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. in American journal of respiratory and critical care medicine 2010
The MUC5B promoter polymorphism is the strongest and the most replicated genetic risk factor for Idiopathic pulmonary fibrosis. It is involved in disease pathogenesis through an increase in MUC5B expression in terminal bronchi and honeycombed cysts.
We propose a mechanism whereby MUC5B decreases surface tension lowering capacity of alveolar surfactant at areas with maximal mechanical stress
These results suggest that MUC5B production can be regulated by ECM (show MMRN1 Antibodies) components and that MUC5B is upregulated by fibronectin (show FN1 Antibodies) and laminin via the integrin, ERK (show EPHB2 Antibodies), and NF-kappaB (show NFKB1 Antibodies) dependent pathway.
MUC5B promoter genotype was not associated with high attenuation areas on lung computed tomography.
Overexpression of MUC5B has been described in idiopathic pulmonary fibrosis lungs. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201507-1322LE#.V2WAGNLrtNs
The variant allele of a common MUC5B promoter variant, rs35705950, is significantly associated with both familial and sporadic idiopathic pulmonary fibrosis. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201509-1872LE#.V2WBpNLrtNs
Mucin 5B promoter polymorphism is associated with the risk for interstitial lung diseases mainly in older male Chinese subjects
MUC5B is a novel prognostic biomarker for patients with non-small cell lung cancer (NSCLC)carrying EGFR (show EGFR Antibodies) mutations but not for patients with NSCLC carrying wild-type EGFR (show EGFR Antibodies)
MUC5B has recently been shown to be associated with idiopathic pulmonary fibrosis susceptibility and survival. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201505-1010OC#.VwqiYdLrvyA
strong association between the MUC5B promoter rs35705950 minor T allele and idiopathic pulmonary fibrosis susceptibility particularly evident in the Caucasian population, milder but still significant in the Asian population [meta-analysis]
Both compounds down regulated mucin (show SLC13A2 Antibodies) 5 subtype B, and peptidoglycan recognition protein 1 (show PGLYRP1 Antibodies) in vaginal tissue
Expressions of Orai1 (show TMEM132A Antibodies), Muc5b, IL-4 (show IL4 Antibodies), IL-5 (show IL5 Antibodies), IL-13 (show IL13 Antibodies) and IL-33 (show IL33 Antibodies) were up-regulated in the allergic state and IL-33 (show IL33 Antibodies) increased the levels of Muc5b, IL-4 (show IL4 Antibodies), IL-5 (show IL5 Antibodies) and IL-13 (show IL13 Antibodies), but did not influence proliferation of T cells.
deleting either the Muc5ac or Muc5b gene is insufficient to create an observable dry eye phenotype on the ocular surface of these mice.
mouse Muc5b (but not Muc5ac) is required for mucociliary clearance, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc5ac is dispensable
Muc5b was detected in all mammary tumors analyzed from MMTV-ras mice
Muc5b is a target gene of transcription factors (TTF-1 (show NKX2-1 Antibodies), GATA-6 (show GATA6 Antibodies)) involved in lung differentiation programs during development and carcinogenesis. TTF-1 (show NKX2-1 Antibodies) is a strong repressor of Muc5b.
analysis of Muc5ac and Muc5b production during prenatal and postnatal murine lung development
Acidic pH drives middle ear epithelial Muc5b gene expression in vitro, which perhaps explains how laryngopharyngeal reflux can contribute to otitis media.
The isolation and characterization of the mouse Muc5b mucin (show SLC13A2 Antibodies) gene (mMuc5b), determined its complete cDNA sequence, its genomic organization, and chromosomal localization and expression.
C-mannosylation is likely required for proper folding of the Cys (show DNAJC5 Antibodies) subdomains and/or for some aspect of ER export during mucin (show SLC13A2 Antibodies) biosynthesis
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.
cervical mucin MUC5B
, high molecular weight salivary mucin MG1
, mucin 5, subtype B, tracheobronchial
, sublingual gland mucin
, ovomucin, alpha-subunit
, mucin 5B, oligomeric mucus/gel-forming
, mucin protein
, mucin 5, subtype B, tracheobronchial-like