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CDHR5 is a novel mucin-like gene that is a member of the cadherin superfamily. Additionally we are shipping CDHR5 Antibodies (59) and CDHR5 Kits (3) and many more products for this protein.
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It suggests that methylation status of MUPCDH promoter can be used as a novel epigenetic biomarker and a therapeutic target in ADPKD.
Study found that brush border assembly is driven by the formation of Ca(2 (show CA2 Proteins)+)-dependent adhesion links between adjacent microvilli. Intermicrovillar links are composed of protocadherin-24 (show CDHR2 Proteins) and mucin-like protocadherin, which target to microvillar tips and interact to form a trans-heterophilic complex.
The transcription factor Cdx2 (show CDX2 Proteins) activates expression of the protocadherin Mucdhl, which interacts with beta-catenin (show CTNNB1 Proteins) and regulates activities of colon cancer cells.
The MUPCDH genetic polymorphism rs3758650 was considered a genetic marker to predict symptomatic Gallstone disease subjects.
Our data consequently suggest that down-regulation of mu-protocadherin expression is a common event in colorectal carcinogenesis and might therefore play an important role in this pathologic process.
identifed the human mu-protocadherin ortholog and examined its expression in the developing kidney
MUCDHL genes are biallelically expressed in multiple fetal and adult tissues both in humans and in mice
This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described.
, mucin and cadherin-like protein
, mucin and cadherin like
, mucin-like protocadherin