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anti-Mucolipin 3 (Mcoln3) Antibodies

Mcoln3 encodes one of members of the mucolipin cation channel proteins. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Mcoln3 171166 Q8R4F0
Mcoln3 55283 Q8TDD5
Mcoln3 308022  
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Top anti-Mucolipin 3 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MCOLN3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: PANC1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB MCOLN3 Antibody (C-term) (ABIN657789) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the MCOLN3 antibody detected the MCOLN3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-MCOLN3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:500Positive Control: HepG2 cell lysate WB Suggested Anti-MCOLN3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.00  Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB Mucolipin 3 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Rat Sheep Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details

Mcoln3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-Mucolipin 3 Antibodies

  1. Mouse (Murine) Polyclonal Mcoln3 Primary Antibody for IHC, WB - ABIN350001 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)
    Show all 2 references for ABIN350001

  2. Human Polyclonal Mcoln3 Primary Antibody for IHC, WB - ABIN350496 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)
    Show all 2 references for ABIN350496

  3. Human Polyclonal Mcoln3 Primary Antibody for WB - ABIN657789 : Kim, Yamaguchi, Li, So, Muallem: Properties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for ABIN657789

  4. Rat (Rattus) Polyclonal Mcoln3 Primary Antibody for IHC, WB - ABIN350495 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)

  5. Cow (Bovine) Polyclonal Mcoln3 Primary Antibody for WB - ABIN2776223 : Kim, Li, Tjon-Kon-Sang, So, Kiselyov, Soyombo, Muallem: A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype. in The EMBO journal 2008 (PubMed)

More Antibodies against Mucolipin 3 Interaction Partners

Mouse (Murine) Mucolipin 3 (Mcoln3) interaction partners

  1. Study shows that, when uropathogenic E. coli infect bladder epithelial cells, they are targeted by autophagy but avoid degradation because of their capacity to neutralize lysosomal pH. This change is detected by TRPML3, TRPML3 activation then spontaneously initiates lysosome exocytosis, resulting in expulsion of exosome-encased bacteria.

  2. Trpml3 inactivation does not lead to hearing and vestibular impairment in mice

  3. Results describe the expression and subcellular distribution of TRPML3 in the inner ear as well as in other sensory organs.

  4. prominent role for MCOLN3 in regulating Ca(2 (show CA2 Antibodies)+) homeostasis at the endosomal pathway

  5. Mutations are associated with deafness and pigmentation defects in varitint-waddler (Va) mice

  6. there is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 (show MCOLN1 Antibodies) and TRPML2 (show MCOLN2 Antibodies) dictate the localization of TRPML3 and not vice versa

  7. TRPML3 is critical for stereocilia bundle formation during development and may function during endocytosis or exocytosis.

  8. This study provides the first direct mechanistic link of a mutation in a TRPML3 with mammalian hearing loss.

  9. TRPML3(A419P) and (I362T+A419P) at physiological potentials may have a role in hair cell degeneration and deafness

  10. The varitint-waddler mouse phenotypes and the TRPML3 ion channel mutation: cause and consequence. (Review)

Human Mucolipin 3 (Mcoln3) interaction partners

  1. these results suggest that TRPML3 plays a role in autophagosome maturation through the interaction with GATE16 (show GABARAPL2 Antibodies), by providing Ca(2 (show CA2 Antibodies)+) in the fusion process.

  2. TRPML3 and TRPV5 (show TRPV5 Antibodies) heteromers could have a biological function

  3. Negatively charged amino acids in the extracellular loops of TRPML3 may interfere with the observed sodium inhibition.

  4. TRPML 1 (show MCOLN1 Antibodies), 2 and 3 assemblies regulated cell viability and starvation-induced autophagy.

  5. analysis of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation

  6. there is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 (show MCOLN1 Antibodies) and TRPML2 (show MCOLN2 Antibodies) dictate the localization of TRPML3 and not vice versa

  7. TRPML3(A419P) and (I362T+A419P) at physiological potentials may have a role in hair cell degeneration and deafness

  8. First characterization of wild-type TRPML3 calcium-permeable channel properties and its regulation by extracytosolic (luminal)hydrogen ion (H+).

  9. The deaf-waddler (show ATP2B2 Antibodies) isoform of PMCA2 (show ATP2B2 Antibodies), operating at 30% efficacy, showed a significantly decreased ability to rescue the Ca(2 (show CA2 Antibodies)+) loading of cells expressing TRPML3(A419P).

  10. Results show that mucolipin 3 is a novel calcium channel that plays a crucial role in the regulation of cargo trafficking along the endosomal pathway.

Mucolipin 3 (Mcoln3) Antigen Profile

Protein Summary

This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Mucolipin 3 (Mcoln3) Antibodies

  • mucolipin 3 (MCOLN3) antibody
  • mucolipin 3 (mcoln3) antibody
  • mucolipin 3 (Mcoln3) antibody
  • 6720490O21Rik antibody
  • MCOLN3 antibody
  • trp-ml3 antibody
  • trpml3 antibody
  • Va antibody

Protein level used designations for anti-Mucolipin 3 (Mcoln3) Antibodies

mucolipin 3 , mucolipin-3-like , mucolipin-3 , varitint-waddler

GENE ID SPECIES
429091 Gallus gallus
469371 Pan troglodytes
549558 Xenopus (Silurana) tropicalis
100064441 Equus caballus
100412379 Callithrix jacchus
100447374 Pongo abelii
100472258 Ailuropoda melanoleuca
100554956 Anolis carolinensis
100591172 Nomascus leucogenys
171166 Mus musculus
55283 Homo sapiens
308022 Rattus norvegicus
444109 Xenopus laevis
490185 Canis lupus familiaris
100049666 Sus scrofa
514345 Bos taurus
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