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Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. Additionally we are shipping Multimerin 1 Kits (16) and Multimerin 1 Proteins (9) and many more products for this protein.
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Our data suggest that multimerin 1 supports platelet adhesive functions and thrombus formation, which will be important to verify by generating and testing selective multimerin 1 deficient mice.
Lower levels of anti-elastin (show ELN Antibodies) are related to CAD (show CAD Antibodies) [ coronary artery disease ]
our studies identify MMRN1 expression as a novel biomarker that may refine acute myelogenous leukemia risk stratification.
multimerin 1 has a role in delivering and localizing factor V onto platelets prior to prothrombinase (show F10 Antibodies) assembly
disulfide-linked complexes of multimerin and factor V in platelets could be important for modulating the function of platelet factor V and its delivery onto activated platelets
MMRN1 is a ligand for alphaIIbbeta3 and alphavbeta3
The MMRN1 binding site was located in Factor V.
Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin (show F2 Antibodies) generation.
MMRN1 supported the adhesion of activated, but not resting, washed platelets over a wide range of shear rates
Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin.
, elastin microfibril interface located protein 4
, elastin microfibril interfacer 4
, endothelial cell multimerin
, glycoprotein Ia*