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Multiple Coagulation Factor Deficiency 2 Proteins (MCFD2)

MCFD2 encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. Additionally we are shipping Multiple Coagulation Factor Deficiency 2 Antibodies (38) and Multiple Coagulation Factor Deficiency 2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MCFD2 90411 Q8NI22
MCFD2 193813 Q8K5B2
MCFD2 246117 Q8K5B3
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Top Multiple Coagulation Factor Deficiency 2 Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human T7 tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,234.83
Details
HOST_Escherichia coli (E. coli) Human T7 tag   1 mg Log in to see 3 to 4 Days
$2,524.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$322.14
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

MCFD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced Multiple Coagulation Factor Deficiency 2 Proteins

  1. Human MCFD2 Protein expressed in Escherichia coli (E. coli) - ABIN666930 : Mohanty, Ghosh, Shetty, Spreafico, Garagiola, Peyvandi: Mutations in the MCFD2 gene and a novel mutation in the LMAN1 gene in Indian families with combined deficiency of factor V and VIII. in American journal of hematology 2005 (PubMed)
    Show all 2 references for ABIN666930

More Proteins for Multiple Coagulation Factor Deficiency 2 (MCFD2) Interaction Partners

Xenopus laevis Multiple Coagulation Factor Deficiency 2 (MCFD2) interaction partners

  1. Results indicate the biological roles of MCFD2 in both vertebrates and invertebrates.

Human Multiple Coagulation Factor Deficiency 2 (MCFD2) interaction partners

  1. A novel missense mutation, namely Asp81Ala in exon 3 of MCFD2 gene, is firstly reported and described as a cause of combined FV and FVIII (show F8 Proteins) deficiency in a Chinese family.

  2. Studies indicate that the LMAN1 (show LMAN1 Proteins)-CRD (show CRX Proteins) contains distinct, separable binding sites for both its partner protein MCFD2 and the cargo proteins FV/FVIII (show F8 Proteins).

  3. Results indicate the biological roles of MCFD2 in both vertebrates and invertebrates.

  4. Data indicate that together with its soluble coreceptor MCFD2, LMAN1 (show LMAN1 Proteins) transports coagulation factors V (FV) and VIII (show COX8A Proteins) (FVIII (show F8 Proteins)).

  5. Mutations in MCFD2 lead to F5F8D (show LMAN1 Proteins) (combined deficiency of factor V And factor VIII) due to alterations in MCFD2-LMAN1 (show LMAN1 Proteins) complex of coat protein (show GOLPH3 Proteins) (COP (show CARD16 Proteins))II complex trafficking machinery; 30% of F5F8D (show LMAN1 Proteins) patients have mutations in MCFD2. [REVIEW]

  6. We present the identification of a novel MCFD2 gene missense mutation by direct sequencing.

  7. The study reports for the first time a case of Combined factor V and factor VIII deficiency disorder in a Tunisian family, resulting from two novel mutations in exon 3 of the MCFD2 gene.

  8. Data present the crystal structure of the LMAN1 (show LMAN1 Proteins)/MCFD2 complex and relate it to patient mutations. Circular dichroism data show that the majority of the substitution mutations give rise to a disordered or severely destabilized MCFD2 protein.

  9. Data show that mutations in MCFD2 that disrupt the tertiary structure and abolish LMAN1 (show LMAN1 Proteins) binding still retain the FV/FVIII (show F8 Proteins) binding activities, suggesting that this interaction is independent of Ca(2 (show CA2 Proteins)+)-induced folding of the protein.

  10. inactivating mutations in MCFD2 cause combined deficiency of factor V and factor VIII with a phenotype indistinguishable from that caused by mutations in LMAN1 (show LMAN1 Proteins)

Mouse (Murine) Multiple Coagulation Factor Deficiency 2 (MCFD2) interaction partners

Multiple Coagulation Factor Deficiency 2 (MCFD2) Protein Profile

Protein Summary

This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 (lectin mannose binding protein 1\; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D)\; a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with MCFD2

  • multiple coagulation factor deficiency 2 (MCFD2)
  • multiple coagulation factor deficiency 2 (mcfd2)
  • multiple coagulation factor deficiency 2 (LOC100353154)
  • multiple coagulation factor deficiency 2 (Mcfd2)
  • 1810021C21Rik protein
  • DKFZp469B098 protein
  • F5f8d protein
  • F5F8D2 protein
  • hm:zeh1186 protein
  • Lman1ip protein
  • MCFD2 protein
  • Sdnsf protein
  • wu:fc23b10 protein
  • wu:fd50d08 protein
  • zgc:103713 protein
  • zgc:109915 protein

Protein level used designations for MCFD2

multiple coagulation factor deficiency 2 , multiple coagulation factor deficiency protein 2 , Multiple coagulation factor deficiency protein 2 homolog , neural stem cell derived neuronal survival protein , neural stem cell-derived neuronal survival protein , multiple coagulation factor deficiency protein 2 homolog , stem cell derived neuronal survival protein

GENE ID SPECIES
421413 Gallus gallus
449676 Danio rerio
459210 Pan troglodytes
474582 Canis lupus familiaris
496472 Xenopus (Silurana) tropicalis
616647 Bos taurus
100137636 Xenopus laevis
100174341 Pongo abelii
100353154 Oryctolagus cuniculus
90411 Homo sapiens
193813 Mus musculus
246117 Rattus norvegicus
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