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Multiple Endocrine Neoplasia I Proteins (MEN1)

MEN1 encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Additionally we are shipping MEN1 Antibodies (101) and MEN1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse MEN1 MEN1 17283 O88559
MEN1 4221 O00255
MEN1 29417 Q9WVR8
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Top MEN1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
Yeast Rat His tag 1 mg Log in to see 56 to 66 Days
$3,760.17
Details
HOST_Human Human Un-conjugated 20 μg Log in to see 9 to 11 Days
$785.40
Details

MEN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human
Rat (Rattus)

More Proteins for Multiple Endocrine Neoplasia I (MEN1) Interaction Partners

Mouse (Murine) Multiple Endocrine Neoplasia I (MEN1) interaction partners

  1. Although mice lacking Men1 developed insulinomas as expected, elimination of ARC (show NOL3 Proteins) in this context did not significantly alter tumor load. Cellular rates of proliferation and death in these tumors were also not perturbed in the absence of ARC (show NOL3 Proteins).

  2. The study characterized the binding position of Ezh2 (show EZH2 Proteins) and menin at all annotated genes in embryonic stem cells and B and T lymphocytes.

  3. Data demonstrate that loss of Men1 in pancreatic islet cells alters the epigenetic landscape of its target genes during early stages of pancreatic neuroendocrine tumor formation.

  4. Data show that menin, encoded by the MEN1 gene, inhibits the transcriptional activity of nuclear receptor liver X receptor alpha (LXRalpha (show NR1H3 Proteins)).

  5. Conditional knockout of beta-catenin (show CTNNB1 Proteins) suppresses the tumorigenesis and growth of Men1-deficient pancreatic neuroendocrine tumors.

  6. miR (show MLXIP Proteins)-802 expression levels are increased in lung carcinoma tissues and targets the tumor suppressor menin and downregulates its expression.

  7. CDK4 (show CDK4 Proteins) is a critical downstream target of MEN1-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 (show CDK2 Proteins) is dispensable for tumorigenesis in these neuroendocrine cell types.

  8. This work shows that Men1 ablation in the pancreatic beta-cells leads to the inactivation of specific transcription factors, resulting in glucagon (show GCG Proteins)-expressing tumor development, which sheds light on the mechanisms of islet tumorigenesis.

  9. Menin regulates spinal glutamate (show GRIN1 Proteins)-GABA balance through GAD65 (show GAD2 Proteins) contributing to neuropathic pain.

  10. Menin orchestrates Th17 cell differentiation and function by regulating both the induction and maintenance of target gene expression.

Human Multiple Endocrine Neoplasia I (MEN1) interaction partners

  1. study to evaluate frequency of Multiple Endocrine Neoplasia type 1 (MEN1) in patients with pituitary adenoma and to perform genetic analysis and familial screening of those with MEN1; genetic analysis showed MEN1 mutations in 4 index cases: IVS4+1 G>A, IVS3-6 C>T, c.1547insC and a new D180A mutation

  2. Study reports the coexistence of a germline intronic heterozygote variation at the MEN1 gene (IVS4+1G>T) and a germline mutation of exon 11 of RET proto-oncogene (show RET Proteins) (K666M) in a large Italian family and describes clinical manifestations in the carriers.

  3. novel MEN1 c.8251G>A mutation in a family with multiple endocrine neoplasia type 1

  4. progenitors. Our findings define SON as a fine-tuner of the MLL (show MLL Proteins)-menin interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia.

  5. interaction between menin and Dnmt1 (show DNMT1 Proteins) reversibly regulates pancreatic cancer cell growth downstream of Hedgehog (show SHH Proteins) pathways with complex mutual modulation networks.

  6. Molecular analysis of sporadic insulinoma (show RPS15 Proteins) revealed presence of three novel exonic mutations, two novel intronic variations, three reported exon SNPs, and one intronic SNP (rs669976).

  7. Data show that menin, encoded by the MEN1 gene, inhibits the transcriptional activity of nuclear receptor liver X receptor alpha (LXRalpha (show NR1H3 Proteins)).

  8. While there appears be a modest link between MEN1 and breast cancer, causality has not so far been demonstrated.

  9. Conditional knockout of beta-catenin (show CTNNB1 Proteins) suppresses the tumorigenesis and growth of Men1-deficient pancreatic neuroendocrine tumors.

  10. miR-17 could inhibit protein levels of Menin through targeting its 3'-untranslated region

MEN1 Protein Profile

Protein Summary

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with MEN1

  • multiple endocrine neoplasia I (men1)
  • multiple endocrine neoplasia I (MEN1)
  • multiple endocrine neoplasia 1 (Men1)
  • multiple endocrine neoplasia I (Men1)
  • AW045611 protein
  • MEAI protein
  • menin protein
  • SCG2 protein

Protein level used designations for MEN1

multiple endocrine neoplasia 1 , menin , multiple endocrine neoplasia I , menin-like , multiple endocrine neoplasia protein

GENE ID SPECIES
549115 Xenopus (Silurana) tropicalis
692344 Felis catus
743979 Pan troglodytes
100158320 Xenopus laevis
100411101 Callithrix jacchus
100441476 Pongo abelii
100472417 Ailuropoda melanoleuca
100538227 Danio rerio
17283 Mus musculus
4221 Homo sapiens
29417 Rattus norvegicus
483758 Canis lupus familiaris
100523533 Sus scrofa
539431 Bos taurus
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