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The protein encoded by MVB12B is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. Additionally we are shipping MVB12B Proteins (4) and MVB12B Antibodies (3) and many more products for this protein.
Study suggests a novel association between SNPs in FAM125B andintra-ocular pressure in the TwinsUK cohort.
The 1.3-A atomic resolution crystal structure of the MVB12B MABP domain reveals a beta (show SUCLA2 ELISA Kits)-prism fold, a hydrophobic membrane-anchoring loop, and an electropositive phosphoinositide-binding patch.
These results suggest that the expression of MVB12B may be normally suppressed through the ubiquitin-proteasome pathway that simultaneously regulates the fate of MVB12A (show FAM125A ELISA Kits) and the functions of ESCRT-I (show VPS28 ELISA Kits).
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ESCRT-I complex subunit MVB12B
, family with sequence similarity 125, member B