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Multivesicular Body Subunit 12B Proteins (MVB12B)

The protein encoded by MVB12B is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. Additionally we are shipping and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MVB12B 89853 Q9H7P6
MVB12B 72543 Q6KAU4
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Top MVB12B Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MVB12B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Multivesicular Body Subunit 12B (MVB12B) Interaction Partners

Human Multivesicular Body Subunit 12B (MVB12B) interaction partners

  1. Study suggests a novel association between SNPs in FAM125B andintra-ocular pressure in the TwinsUK cohort.

  2. The 1.3-A atomic resolution crystal structure of the MVB12B MABP domain reveals a beta (show SUCLA2 Proteins)-prism fold, a hydrophobic membrane-anchoring loop, and an electropositive phosphoinositide-binding patch.

  3. These results suggest that the expression of MVB12B may be normally suppressed through the ubiquitin-proteasome pathway that simultaneously regulates the fate of MVB12A (show FAM125A Proteins) and the functions of ESCRT-I (show VPS28 Proteins).

MVB12B Protein Profile

Protein Summary

The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MVB12B

  • multivesicular body subunit 12B (MVB12B)
  • multivesicular body subunit 12B (Mvb12b)
  • 2610200O14Rik protein
  • 2610528K11Rik protein
  • AI414895 protein
  • C9orf28 protein
  • Fam125b protein

Protein level used designations for MVB12B

ESCRT-I complex subunit MVB12B , family with sequence similarity 125, member B

GENE ID SPECIES
89853 Homo sapiens
72543 Mus musculus
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