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anti-Muscleblind-Like 1 (Drosophila) (MBNL1) Antibodies

Involved in pre-mRNA alternative splicing regulation. Additionally we are shipping MBNL1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse MBNL1 MBNL1 56758 Q9JKP5
MBNL1 4154 Q9NR56
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Top anti-MBNL1 Antibodies at antibodies-online.com

Showing 5 out of 8 products:

Catalog No. Reactivity Host Conjugate Application Quantity Supplier Delivery Price Details
Human Rabbit HRP ELISA, WB 100 μg Log in to see 9 to 11 Days
$328.90
Details
Human Rabbit FITC 100 μg Log in to see 9 to 19 Days
$432.73
Details
Human Rabbit Biotin 100 μg Log in to see 9 to 19 Days
$432.73
Details
Human Rabbit HRP 100 μg Log in to see 9 to 19 Days
$432.73
Details
Human Rabbit Un-conjugated 100 μg Log in to see 9 to 19 Days
$432.73
Details

MBNL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human


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More Antibodies against MBNL1 Interaction Partners

Mouse (Murine) Muscleblind-Like 1 (Drosophila) (MBNL1) interaction partners

  1. Depletion of Mbnl1 and/or Mbnl2 (show MBNL2 Antibodies) reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  2. Sense DMPK (show DMPK Antibodies) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  3. MBNL1 overexpression promotes transformation of fibroblasts into myofibroblasts.

  4. These data indicate that MBNL1 plays a conserved role in negatively regulating TGFbeta (show TGFB1 Antibodies) signaling, and is required for normal valve morphogenesis and homeostasis in vivo.

  5. this study supports a key role for Mbnl1 loss in the initiation of DM1 cardiac disease.

  6. Differential expression of Mbnl1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.

  7. Results show that nuclear localization is a major determinant of MBNL1 function. It promotes the nuclear retention of repeat-containing transcripts, which results in repression of aberrant protein expression from the expanded repeats.

  8. depletion of Mbnl proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  9. consistent with a central and negative regulatory role for MBNL proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  10. MBNL1 overexpression may be a valuable strategy for treating the skeletal muscle features of Myotonic dystrophy .

Human Muscleblind-Like 1 (Drosophila) (MBNL1) interaction partners

  1. Nuclear retention of full-length HTT (show HTT Antibodies) RNA is mediated by splicing factors MBNL1 and U2AF65 (show U2AF59 Antibodies)

  2. muscleblind-like 1 (MBNL1) is a robust suppressor of multiorgan breast cancer metastasis. It binds the 3' untranslated regions of DBNL (show DBNL Antibodies) and TACC1 (show TACC1 Antibodies) -two genes that are implicated as metastasis suppressors.

  3. Sense DMPK (show DMPK Antibodies) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  4. abnormal splicing of DMD (show DMD Antibodies) exon 78 found in dystrophic muscles of DM1 (show DMPK Antibodies) patients is due to the functional loss of MBNL1 and leads to the re-expression of an embryonic dystrophin (show DMD Antibodies) in place of the adult isoform.

  5. Reduced RBFOX1 (show A2BP1 Antibodies) activity in myotonic dystrophy type 1 tissues may amplify several of the splicing alterations caused by the deficiency in MBNL1.

  6. MBNL1 binds with C allelic pre-miR (show MLXIP Antibodies)-1307 leading to low expression of miR (show MLXIP Antibodies)-1307-3p in colorectal cancer.

  7. The result is consistent with the hypothesis that MBNL proteins are trapped by expanded CUG repeats and inactivated in myotonic dystrophy type 1 (DM1) and that CELF1 is activated in DM1.

  8. Results show that nuclear localization is a major determinant of MBNL1 function. It promotes the nuclear retention of repeat-containing transcripts, which results in repression of aberrant protein expression from the expanded repeats.

  9. Results highlight the importance of RNA binding by MBNL Zinc Finger domains 1 and 2 for splicing regulatory activity, even when the protein is artificially recruited to its regulatory location on target RNAs.

  10. both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both.

MBNL1 Antigen Profile

Protein Summary

Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA (By similarity).

Gene names and symbols associated with MBNL1

  • muscleblind-like (Drosophila) (MBNL1) antibody
  • muscleblind-like 1 (Drosophila) (Mbnl1) antibody
  • muscleblind-like splicing regulator 1 (MBNL1) antibody
  • EXP antibody
  • EXP35 antibody
  • EXP40 antibody
  • EXP42 antibody
  • MBNL antibody
  • mKIAA0428 antibody

Protein level used designations for MBNL1

muscleblind-like 1 , muscleblind-like protein 1 , triplet-expansion RNA-binding protein

GENE ID SPECIES
425033 Gallus gallus
56758 Mus musculus
4154 Homo sapiens
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