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Muscleblind-Like 2 (Drosophila) Proteins (MBNL2)

MBNL2 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. Additionally we are shipping MBNL2 Antibodies (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MBNL2 105559 Q8C181
MBNL2 10150 Q5VZF2
MBNL2 680445 F2Z3T4
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Top MBNL2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,023.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MBNL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for Muscleblind-Like 2 (Drosophila) (MBNL2) Interaction Partners

Mouse (Murine) Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Depletion of Mbnl1 (show MBNL1 Proteins) and/or Mbnl2 reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  2. Sense DMPK (show DMPK Proteins) RNA foci clearly co-localize with MBNL1 (show MBNL1 Proteins) and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  3. depletion of Mbnl (show MBNL1 Proteins) proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  4. consistent with a central and negative regulatory role for MBNL (show MBNL1 Proteins) proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  5. This analysis identified several hundred splicing events whose regulation depended on Mbnl (show MBNL1 Proteins) function in a pattern indicating functional interchangeability between Mbnl1 (show MBNL1 Proteins) and Mbnl2.

  6. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  7. Conserved developmental stage- and tissue-specific alternative splicing of MBNL (show MBNL1 Proteins) transcripts is an important mechanism by which MBNL (show MBNL1 Proteins) activity is regulated during embryonic development.

  8. The authors propose that expanded CTG DNA repeats cause two separate effects: loss of Mbnl1 (show MBNL1 Proteins) function (disrupting splicing) and loss of another function that disrupts extracellular matrix mRNA regulation, possibly mediated by Mbnl2.

  9. MBNL2 contribute to the pathogenesis of myotonic dystrophy.

Zebrafish Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. MBNL2 in splicing regulation of specific transcripts, which, when altered, contributes to the myotonic dystrophy phenotype.

Human Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Sense DMPK (show DMPK Proteins) RNA foci clearly co-localize with MBNL1 (show MBNL1 Proteins) and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  2. both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both

  3. consistent with a central and negative regulatory role for MBNL (show MBNL1 Proteins) proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  4. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  5. MBNL (show MBNL1 Proteins) proteins promote opposite splicing patterns for cardiac troponin T (show TNNT2 Proteins) and insulin receptor (show INSR Proteins) alternative exons

  6. MBNL1 (show MBNL1 Proteins) and MBNL2 always co-distributed. Functional differences between MBNL1 (show MBNL1 Proteins) and MBNL2 have not yet been found

  7. solution structures of both tandem zinc finger (TZF) motifs, TZF12 (comprising ZF1 (show PRMT1 Proteins) and ZF2 (show ZNF274 Proteins)) and TZF34 (ZF3 and ZF4), in MBNL2

MBNL2 Protein Profile

Protein Summary

This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.

Gene names and symbols associated with MBNL2

  • muscleblind-like 2 (Mbnl2)
  • muscleblind-like 2 (Drosophila) (mbnl2)
  • muscleblind-like 2 (Drosophila) (MBNL2)
  • muscleblind-like splicing regulator 2 (MBNL2)
  • muscleblind-like splicing regulator 2 (Mbnl2)
  • 1110002M11Rik protein
  • AI047808 protein
  • AI837313 protein
  • AI849185 protein
  • AL118326 protein
  • MBLL protein
  • MBLL39 protein
  • mKIAA4072 protein
  • PRO2032 protein
  • R75232 protein
  • wu:fj89c04 protein

Protein level used designations for MBNL2

muscleblind-like protein 2 , fj89c04 , muscleblind-like 2 , muscleblind-like protein 1 , muscleblind-like protein-like 39

GENE ID SPECIES
105559 Mus musculus
560384 Danio rerio
418784 Gallus gallus
527679 Bos taurus
10150 Homo sapiens
612815 Canis lupus familiaris
680445 Rattus norvegicus
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