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MCC is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. Additionally we are shipping MCC Proteins (4) and many more products for this protein.
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Human Monoclonal MCC Primary Antibody for IHC (f), IF - ABIN968147
Ashton-Rickardt, Wyllie, Bird, Dunlop, Steel, Morris, Piris, Romanowski, Wood, White: MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer. in Oncogene 1991
Show all 5 Pubmed References
The PDZ domain protein (show INADL Antibodies) Mcc is a novel effector of non-canonical Wnt (show WNT2 Antibodies) signaling during convergence and extension in zebrafish.
Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene (show RAB1A Antibodies) in B cells
cytoplasmic MCC-DBC1 (show DBC1 Antibodies) interaction sequesters DBC1 (show DBC1 Antibodies) away from the nucleus, thereby removing a brake on DBC1 (show DBC1 Antibodies) nuclear targets, such as SIRT1 (show SIRT1 Antibodies)
targeted by miR (show MLXIP Antibodies)-494, which is overexpressed in hepatocellular carcinoma
MCC regulates lamellipodia formation by binding to Scrib (show SCRIB Antibodies) and its downstream partner Myosin-IIB (show MYH10 Antibodies) in a multiprotein complex.
we have shown that promoter methylation of the APC (show APC Antibodies) gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci.
Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer.
MCC is a nuclear, beta-catenin-interacting protein (show CTNNBIP1 Antibodies) that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signal transduction.
Results identify MCC as a potential scaffold protein (show HOMER1 Antibodies) regulating cell movement and able to bind Scrib (show SCRIB Antibodies), beta-catenin (show CTNNB1 Antibodies) and NHERF1 (show SLC9A3R1 Antibodies)/2.
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
mutated in colorectal cancers
, colorectal mutant cancer protein