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anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) Antibodies

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Additionally we are shipping MYSM1 Kits (4) and MYSM1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MYSM1 114803 Q5VVJ2
MYSM1 320713 Q69Z66
MYSM1 298247  
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Top anti-MYSM1 Antibodies at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram) using MYSM1 Antibody (N-term), followed by FITC-conjugated goat-anti-rabbit secondary antibodies. Western blot analysis in MDA-MB231 cell line lysates (35ug/lane) using MYSM1 Antibody (N-term). This demonstrates this antibody detected the MYSM1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using MYSM1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: MYSM1  Sample Tissue: Fetal Liver lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: MYSM1  Sample Tissue: Hela Whole Cell lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, WB MYSM1 Antibody (N-term) (ABIN654474) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit APC FACS, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IHC, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details

MYSM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) , ,


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Top referenced anti-MYSM1 Antibodies

  1. Human Polyclonal MYSM1 Primary Antibody for EIA, FACS - ABIN953592 : Zhu, Zhou, Wang, Puc, Ohgi, Erdjument-Bromage, Tempst, Glass, Rosenfeld: A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. in Molecular cell 2007 (PubMed)
    Show all 4 references for ABIN953592

  2. Human Polyclonal MYSM1 Primary Antibody for IHC, ELISA - ABIN1535215 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)
    Show all 2 references for ABIN1535215

More Antibodies against MYSM1 Interaction Partners

Human Myb-Like, SWIRM and MPN Domains 1 (MYSM1) interaction partners

  1. An in vivo genetic reversion highlights the crucial role of MYSM1 in human hematopoiesis and lymphocyte differentiation

  2. the biallelic truncation of MYSM1 likely represents the cause of an inherited bone marrow failure syndrome in two siblings

  3. The SWIRM structure of human MYb (show MYB Antibodies)-like, Swirm and Mpn domain-containing protein (show MPND Antibodies)-1 (MYSM1), is reported.

  4. The identification of histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that helps in delineating a strategy for specific regulatory pathways of gene activation, is reported.

Mouse (Murine) Myb-Like, SWIRM and MPN Domains 1 (MYSM1) interaction partners

  1. this study uncovers a critical role for MYSM1 in epigenetically repressing plasma cell differentiation and antibody production, in addition to its opposing, active role in B cell development.

  2. MYSM1 is essential for normal HSC (show FUT1 Antibodies) function and progression of hematopoiesis in the fetal liver and HSC (show FUT1 Antibodies) maintenance in adult bone marrow.

  3. 2 motifs in MYSM1 are essential for innate immune suppression: the SWIRM domain that interacts with TRAF3 (show TRAF3 Antibodies) and TRAF6 (show TRAF6 Antibodies) and the metalloproteinase domain that removed K63 polyubiquitins. MYSM1 is a key negative regulator of the innate immune system

  4. Loss of hematopoietic stem cell function and bone marrow failure in Mysm1-knockout mice are the result of p53 (show TP53 Antibodies) activation.

  5. Data indicate that histone H2A deubiquitinase Mysm1 is required for dendritic cell development.

  6. Mysm1-mediated epigenetic regulation has a role in controlling hematopoietic stem cell maintenance, self-renewal, and differentiation

  7. MYSM1 is required for natural killer cell maturation, including the the recruitment of nuclear factor Il-3 to the ID2 locus.

  8. Data indicate a role for histone H2A-deubiquitinase Mysm1 in the maintenance of bone marrow stem cell function, in the control of oxidative stress and genetic stability in hematopoietic progenitors.

  9. MYSM1 derepresses EBF1 (show EBF1 Antibodies) transcription in B cell progenitors by orchestrating histone modifications and transcription factor recruitment to the EBF1 (show EBF1 Antibodies) locus.

MYSM1 Antigen Profile

Protein Summary

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).

Gene names and symbols associated with MYSM1

  • Myb-like, SWIRM and MPN domains 1 (MYSM1) antibody
  • myb-like, SWIRM and MPN domains 1 (Mysm1) antibody
  • myb-like, SWIRM and MPN domains 1 (MYSM1) antibody
  • myb-like, SWIRM and MPN domains 1 (mysm1) antibody
  • 2A-DUB antibody
  • 2adub antibody
  • C130067A03Rik antibody
  • C530050H10Rik antibody
  • RGD1311787 antibody
  • RP4-592A1.1 antibody

Protein level used designations for MYSM1

histone H2A deubiquitinase MYSM1 , myb-like, SWIRM and MPN domain-containing protein 1 , 2A-DUB , Myb-like, SWIRM and MPN domain-containing protein 1

GENE ID SPECIES
114803 Homo sapiens
320713 Mus musculus
298247 Rattus norvegicus
424671 Gallus gallus
779416 Xenopus laevis
Selected quality suppliers for anti-MYSM1 (MYSM1) Antibodies
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