anti-Mycn (MYCN) Antibodies

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Additionally we are shipping MYCN Proteins (7) and MYCN Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
MYCN 298894 Q63379
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Top anti-MYCN Antibodies at antibodies-online.com

Showing 10 out of 98 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB 100 μL Log in to see 3 to 7 Days
$318.45
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of MYCN antibody (C-term) (ABIN391590) in CEM cell line lysates (35 µg/lane). MYCN (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of MYCN antibody (C-term) in CEM cell line lysates (35ug/lane). MYCN (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ChIP, CyTOF, FACS, GS, ICC, IF, IP, WB Immunocytochemistry/ Immunofluorescence: n-Myc Antibody (NMYC-1) [ABIN152254] - The n-Myc (NMYC-1) antibody was tested in NTERA2 cells at a 1:50 dilution against Dylight 488 (Green). Actin and nuclei were counterstained against Phalloidin 568 (Red) and DAPI (Blue), respectively. Western Blot: n-Myc Antibody (NMYC-1) [ABIN152254] - Western blot analysis of n-Myc expression in human heart tissue. 0.1 mL Log in to see 7 to 9 Days
$444.19
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, WB The n-Myc Antibody is used in Western blot to detect Myc in human fetal kidney lysate. 0.1 mg Log in to see 2 to 6 Days
$327.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of MYCN expression in transfected 293T cell line by MYCN monoclonal antibody (M01), clone 3H4. Lane 1: MYCN transfected lysate(49.6 KDa). Lane 2: Non-transfected lysate. Western blot analysis of MYCN over-expressed 293 cell line, cotransfected with MYCN Validated Chimera RNAi used as specificity and loading control. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$537.17
Details

MYCN Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-MYCN Antibodies

  1. Human Monoclonal MYCN Primary Antibody for ChIP, CyTOF - ABIN152254 : Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. in The Journal of biological chemistry 2011 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal MYCN Primary Antibody for ICC, IF - ABIN256650 : Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. in Developmental cell 2005 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal MYCN Primary Antibody for IF (p), IHC (p) - ABIN760676 : Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. in Oncotarget 2016 (PubMed)

  4. Human Polyclonal MYCN Primary Antibody for WB - ABIN391590 : Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. in Molecular cancer research : MCR 2015 (PubMed)

More Antibodies against MYCN Interaction Partners

Human Mycn (MYCN) interaction partners

  1. data extend knowledge on roles of MCPIP1 (show ZC3H12A Antibodies) in our model and link the protein to regulation of expression and stability of MYCN through decrease of signaling via Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway.

  2. Data show that MYCN and its regulated microRNAs acted together to repress the tumor suppressor genes.

  3. Common genetic variation predisposes to different neuroblastoma (show ARHGEF16 Antibodies) genotypes, including the likelihood of somatic MYCN-amplification. [meta-analysis]

  4. Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (show RB1 Antibodies) gene.

  5. The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (show ARHGEF16 Antibodies), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (show ARHGEF16 Antibodies).

  6. Many prognostic signatures for neuroblastoma (show ARHGEF16 Antibodies) are confounded by MYCN amplification.

  7. Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.

  8. miR (show MLXIP Antibodies)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (show CADM1 Antibodies), and an inverse correlation between miR (show MLXIP Antibodies)-21 and CADM1 (show CADM1 Antibodies) expression in vivo. MiR (show MLXIP Antibodies)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer

  9. LMO1 (show LMO1 Antibodies) is an important oncogene (show RAB1A Antibodies) that promotes neuroblastoma (show ARHGEF16 Antibodies) initiation, progression, and widespread metastatic dissemination.

  10. our results identify DOT1L (show DOT1L Antibodies) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (show ARHGEF16 Antibodies) oncogenesis. Furthermore, they characterize DOT1L (show DOT1L Antibodies) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (show ARHGEF16 Antibodies).

Mouse (Murine) Mycn (MYCN) interaction partners

  1. interactions of NF-kappaB (show NFKB1 Antibodies) and N-myc with GLT-1/EAAT2 (show SLC1A2 Antibodies) promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.

  2. beta-catenin (show CTNNB1 Antibodies) cooperates with the transcription factor Myc (show MYC Antibodies) to activate the progenitor renewal program.

  3. we report the isolation and propagation of neuroblastoma (show ARHGEF16 Antibodies) sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma (show ARHGEF16 Antibodies) with MYCN amplification

  4. miR (show MLXIP Antibodies)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.

  5. the role of N-myc in mouse lens development, was examined.

  6. Using comparative genomic hybridization, authors found that NCC (show SLC12A3 Antibodies)-derived NBL (show NUMBL Antibodies) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (show NUMBL Antibodies) including 17q gain, 2p gain and loss of 1p36.

  7. a Mycn target gene encoding the miR (show MLXIP Antibodies) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  8. The findings reveal a PLK1 (show PLK1 Antibodies)-Fbw7 (show FBXW7 Antibodies)-Myc (show MYC Antibodies) signaling circuit that underlies tumorigenesis and validate PLK1 (show PLK1 Antibodies) inhibitors, alone or with Bcl2 (show BCL2 Antibodies) antagonists, as potential effective therapeutics for MYC (show MYC Antibodies)-overexpressing cancers.

  9. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (show MMRN1 Antibodies)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  10. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

Zebrafish Mycn (MYCN) interaction partners

  1. In MYCN transgenic fish, Gab2 (show GAB2 Antibodies) overexpression activated the Shp2 (show PTPN11 Antibodies)-Ras (show RAB1A Antibodies)-Erk (show MAPK1 Antibodies) pathway, enhanced neuroblastoma (show ARHGEF16 Antibodies) induction, and increased tumor penetrance.

  2. The authors demonstrate in zebrafish that nf1 (show NF1 Antibodies) loss leads to aberrant activation of RAS (show RAB1A Antibodies) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (show ARHGEF16 Antibodies) in nf1 (show NF1 Antibodies)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (show NF1 Antibodies) mutant embryos.

  3. At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.

MYCN Antigen Profile

Protein Summary

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Gene names and symbols associated with anti-Mycn (MYCN) Antibodies

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) antibody
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) antibody
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) antibody
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) antibody
  • olfactory receptor 8S1 (LOC515887) antibody
  • MYCN proto-oncogene, bHLH transcription factor (mycn) antibody
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) antibody
  • bHLHe37 antibody
  • c-nmyc antibody
  • fb57a02 antibody
  • MODED antibody
  • mycn antibody
  • mycn-a antibody
  • mycn-b antibody
  • mycna antibody
  • MYCNOT antibody
  • N-myc antibody
  • Nmuc1 antibody
  • Nmyc antibody
  • Nmyc-1 antibody
  • nmyc1 antibody
  • ODED antibody
  • wu:fb57a02 antibody
  • XN-myc antibody
  • xN-myc1 antibody
  • XNmyc antibody
  • zgc:85706 antibody

Protein level used designations for anti-Mycn (MYCN) Antibodies

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPECIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
Selected quality suppliers for anti-MYCN (MYCN) Antibodies
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