Mycn (MYCN) ELISA Kits

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Additionally we are shipping MYCN Antibodies (99) and MYCN Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
MYCN 298894 Q63379
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Top MYCN ELISA Kits at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Rat 0.312-20 ng/mL   96 Tests Log in to see 2 to 3 Days
$779.90
Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$946.00
Details
Chicken
  96 Tests Log in to see 15 to 18 Days
$1,095.60
Details

More ELISA Kits for MYCN Interaction Partners

Human Mycn (MYCN) interaction partners

  1. Data indicate cross-talks between MYCN and beta-catenin (show CTNNB1 ELISA Kits) signalling, which repress normal beta-catenin (show CTNNB1 ELISA Kits) mediated transcriptional regulation.

  2. Data show that transcription factor activating enhancer binding protein-4 (TFAP4) is a direct transcriptional target of MYCN in neuroblastoma (show ARHGEF16 ELISA Kits) and that high levels of this transcription factor are associated with poor clinical outcome in this disease.

  3. data extend knowledge on roles of MCPIP1 (show ZC3H12A ELISA Kits) in our model and link the protein to regulation of expression and stability of MYCN through decrease of signaling via Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) pathway.

  4. Data show that MYCN and its regulated microRNAs acted together to repress the tumor suppressor genes.

  5. Common genetic variation predisposes to different neuroblastoma (show ARHGEF16 ELISA Kits) genotypes, including the likelihood of somatic MYCN-amplification. [meta-analysis]

  6. Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (show RB1 ELISA Kits) gene.

  7. The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (show ARHGEF16 ELISA Kits), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (show ARHGEF16 ELISA Kits).

  8. Many prognostic signatures for neuroblastoma (show ARHGEF16 ELISA Kits) are confounded by MYCN amplification.

  9. Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.

  10. miR (show MLXIP ELISA Kits)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (show CADM1 ELISA Kits), and an inverse correlation between miR (show MLXIP ELISA Kits)-21 and CADM1 (show CADM1 ELISA Kits) expression in vivo. MiR (show MLXIP ELISA Kits)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer

Mouse (Murine) Mycn (MYCN) interaction partners

  1. interactions of NF-kappaB (show NFKB1 ELISA Kits) and N-myc with GLT-1/EAAT2 (show SLC1A2 ELISA Kits) promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.

  2. beta-catenin (show CTNNB1 ELISA Kits) cooperates with the transcription factor Myc (show MYC ELISA Kits) to activate the progenitor renewal program.

  3. we report the isolation and propagation of neuroblastoma (show ARHGEF16 ELISA Kits) sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma (show ARHGEF16 ELISA Kits) with MYCN amplification

  4. miR (show MLXIP ELISA Kits)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.

  5. the role of N-myc in mouse lens development, was examined.

  6. Using comparative genomic hybridization, authors found that NCC (show SLC12A3 ELISA Kits)-derived NBL (show NUMBL ELISA Kits) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (show NUMBL ELISA Kits) including 17q gain, 2p gain and loss of 1p36.

  7. a Mycn target gene encoding the miR (show MLXIP ELISA Kits) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  8. The findings reveal a PLK1 (show PLK1 ELISA Kits)-Fbw7 (show FBXW7 ELISA Kits)-Myc (show MYC ELISA Kits) signaling circuit that underlies tumorigenesis and validate PLK1 (show PLK1 ELISA Kits) inhibitors, alone or with Bcl2 (show BCL2 ELISA Kits) antagonists, as potential effective therapeutics for MYC (show MYC ELISA Kits)-overexpressing cancers.

  9. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (show MMRN1 ELISA Kits)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  10. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

Zebrafish Mycn (MYCN) interaction partners

  1. In MYCN transgenic fish, Gab2 (show GAB2 ELISA Kits) overexpression activated the Shp2 (show PTPN11 ELISA Kits)-Ras (show RAB1A ELISA Kits)-Erk (show MAPK1 ELISA Kits) pathway, enhanced neuroblastoma (show ARHGEF16 ELISA Kits) induction, and increased tumor penetrance.

  2. The authors demonstrate in zebrafish that nf1 (show NF1 ELISA Kits) loss leads to aberrant activation of RAS (show RAB1A ELISA Kits) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (show ARHGEF16 ELISA Kits) in nf1 (show NF1 ELISA Kits)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (show NF1 ELISA Kits) mutant embryos.

  3. At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.

MYCN Antigen Profile

Antigen Summary

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Gene names and symbols associated with Mycn (MYCN) ELISA Kits

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) antibody
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) antibody
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) antibody
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) antibody
  • olfactory receptor 8S1 (LOC515887) antibody
  • MYCN proto-oncogene, bHLH transcription factor (mycn) antibody
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) antibody
  • bHLHe37 antibody
  • c-nmyc antibody
  • fb57a02 antibody
  • MODED antibody
  • mycn antibody
  • mycn-a antibody
  • mycn-b antibody
  • mycna antibody
  • MYCNOT antibody
  • N-myc antibody
  • Nmuc1 antibody
  • Nmyc antibody
  • Nmyc-1 antibody
  • nmyc1 antibody
  • ODED antibody
  • wu:fb57a02 antibody
  • XN-myc antibody
  • xN-myc1 antibody
  • XNmyc antibody
  • zgc:85706 antibody

Protein level used designations for Mycn (MYCN) ELISA Kits

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPECIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
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