Mycn Proteins (MYCN)

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Additionally we are shipping MYCN Antibodies (97) and MYCN Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYCN 4613 P04198
Rat MYCN MYCN 298894 Q63379
MYCN 18109 P03966
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Top MYCN Proteins at antibodies-online.com

Showing 6 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Yeast Serinus canaria His tag   1 mg Log in to see 60 to 71 Days
$3,191.83
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$3,234.00
Details
Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
Details

MYCN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced MYCN Proteins

  1. Human MYCN Protein expressed in Wheat germ - ABIN1311728 : Smith, Womack: A matrix approach to guide IHC-based tissue biomarker development in oncology drug discovery. in The Journal of pathology 2013 (PubMed)
    Show all 3 Pubmed References

More Proteins for Mycn (MYCN) Interaction Partners

Human Mycn (MYCN) interaction partners

  1. Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (show RB1 Proteins) gene.

  2. USP7 (show USP7 Proteins) deubiquitinates MYCN to enhance its stability and transcriptional activity in neuroblastoma (show ARHGEF16 Proteins).

  3. The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (show ARHGEF16 Proteins), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (show ARHGEF16 Proteins).

  4. Many prognostic signatures for neuroblastoma (show ARHGEF16 Proteins) are confounded by MYCN amplification.

  5. Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.

  6. miR (show MLXIP Proteins)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (show CADM1 Proteins), and an inverse correlation between miR (show MLXIP Proteins)-21 and CADM1 (show CADM1 Proteins) expression in vivo. MiR (show MLXIP Proteins)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer

  7. LMO1 (show LMO1 Proteins) is an important oncogene (show RAB1A Proteins) that promotes neuroblastoma (show ARHGEF16 Proteins) initiation, progression, and widespread metastatic dissemination.

  8. our results identify DOT1L (show DOT1L Proteins) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (show ARHGEF16 Proteins) oncogenesis. Furthermore, they characterize DOT1L (show DOT1L Proteins) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (show ARHGEF16 Proteins).

  9. CCCTC-binding factor (CTCF (show CTCF Proteins)) targets the binding sites within MYCN promoter to facilitate its expression in neuroblastoma (show ARHGEF16 Proteins) (NB) cells.

  10. PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins) collaborates with MYCN during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.

Mouse (Murine) Mycn (MYCN) interaction partners

  1. the role of N-myc in mouse lens development, was examined.

  2. Using comparative genomic hybridization, authors found that NCC (show SLC12A3 Proteins)-derived NBL (show NUMBL Proteins) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (show NUMBL Proteins) including 17q gain, 2p gain and loss of 1p36.

  3. a Mycn target gene encoding the miR (show MLXIP Proteins) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  4. The findings reveal a PLK1-Fbw7 (show FBXW7 Proteins)-Myc (show MYC Proteins) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (show BCL2 Proteins) antagonists, as potential effective therapeutics for MYC (show MYC Proteins)-overexpressing cancers.

  5. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (show MMRN1 Proteins)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  6. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

  7. Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma (show ARHGEF16 Proteins), and is a promising approach for further clinical development.

  8. demonstrate a critical link between Myc (show MYC Proteins)/Mycn gene activity and glycolysis in spermatogonial stem cell self-renewal

  9. Loss of N-myc significantly impairs the Sonic hedgehog (show SHH Proteins) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (show CCND2 Proteins).

  10. Study shows that ground-state embryonic stem cells express low Myc (show MYC Proteins) levels. Deletion of both c-myc (show MYC Proteins) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (show MYC Proteins)-depleted stem cells enter a state of dormancy.

MYCN Protein Profile

Protein Summary

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Gene names and symbols associated with Mycn Proteins (MYCN)

  • olfactory receptor, family 8, subfamily S, member 1-like (LOC515887)
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN)
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (Mycn)
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (MYCN)
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN)
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (Mycn)
  • bHLHe37 protein
  • c-nmyc protein
  • MODED protein
  • MYCNOT protein
  • N-myc protein
  • Nmuc1 protein
  • Nmyc protein
  • Nmyc-1 protein
  • Nmyc1 protein
  • ODED protein

Protein level used designations for Mycn Proteins (MYCN)

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc protein , neuroblastoma myc-related oncogene 1

GENE ID SPECIES
515887 Bos taurus
4613 Homo sapiens
298894 Rattus norvegicus
421948 Gallus gallus
482978 Canis lupus familiaris
18109 Mus musculus
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