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MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Additionally we are shipping MYCN Antibodies (97) and MYCN Kits (6) and many more products for this protein.
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Human MYCN Protein expressed in Wheat germ - ABIN1311728
Smith, Womack: A matrix approach to guide IHC-based tissue biomarker development in oncology drug discovery. in The Journal of pathology 2013
Show all 3 Pubmed References
Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (show RB1 Proteins) gene.
USP7 (show USP7 Proteins) deubiquitinates MYCN to enhance its stability and transcriptional activity in neuroblastoma (show ARHGEF16 Proteins).
The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (show ARHGEF16 Proteins), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (show ARHGEF16 Proteins).
Many prognostic signatures for neuroblastoma (show ARHGEF16 Proteins) are confounded by MYCN amplification.
Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.
miR (show MLXIP Proteins)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (show CADM1 Proteins), and an inverse correlation between miR (show MLXIP Proteins)-21 and CADM1 (show CADM1 Proteins) expression in vivo. MiR (show MLXIP Proteins)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer
LMO1 (show LMO1 Proteins) is an important oncogene (show RAB1A Proteins) that promotes neuroblastoma (show ARHGEF16 Proteins) initiation, progression, and widespread metastatic dissemination.
our results identify DOT1L (show DOT1L Proteins) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (show ARHGEF16 Proteins) oncogenesis. Furthermore, they characterize DOT1L (show DOT1L Proteins) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (show ARHGEF16 Proteins).
CCCTC-binding factor (CTCF (show CTCF Proteins)) targets the binding sites within MYCN promoter to facilitate its expression in neuroblastoma (show ARHGEF16 Proteins) (NB) cells.
PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins) collaborates with MYCN during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.
the role of N-myc in mouse lens development, was examined.
Using comparative genomic hybridization, authors found that NCC (show SLC12A3 Proteins)-derived NBL (show NUMBL Proteins) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (show NUMBL Proteins) including 17q gain, 2p gain and loss of 1p36.
a Mycn target gene encoding the miR (show MLXIP Proteins) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.
The findings reveal a PLK1-Fbw7 (show FBXW7 Proteins)-Myc (show MYC Proteins) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (show BCL2 Proteins) antagonists, as potential effective therapeutics for MYC (show MYC Proteins)-overexpressing cancers.
ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (show MMRN1 Proteins)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.
Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.
Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma (show ARHGEF16 Proteins), and is a promising approach for further clinical development.
demonstrate a critical link between Myc (show MYC Proteins)/Mycn gene activity and glycolysis in spermatogonial stem cell self-renewal
Loss of N-myc significantly impairs the Sonic hedgehog (show SHH Proteins) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (show CCND2 Proteins).
Study shows that ground-state embryonic stem cells express low Myc (show MYC Proteins) levels. Deletion of both c-myc (show MYC Proteins) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (show MYC Proteins)-depleted stem cells enter a state of dormancy.
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
N-myc proto-oncogene protein
, class E basic helix-loop-helix protein 37
, neuroblastoma MYC oncogene
, neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
, oncogene NMYC
, v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
, Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc)
, Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc)
, N-myc protein
, neuroblastoma myc-related oncogene 1