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The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. Additionally we are shipping Myelin Basic Protein Antibodies (197) and Myelin Basic Protein Kits (43) and many more products for this protein.
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Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.
This study observed a significantly increased myelin basic protein (MBP) and nuclear distribution protein nudE-like 1 (NDEL1 (show NDEL1 Proteins)) mRNA levels in FEP patients compared with controls.
myelin basic protein has a role in activating CD4 (show CD4 Proteins)+ and CD8 (show CD8A Proteins)+ T lymphocytes in multiple sclerosis
B cells from relapsing-remitting multiple sclerosis patients produce TNFa (show TNF Proteins) and IL6 (show IL6 Proteins), and present MBP85-99 peptide
IL-17 (show IL17A Proteins)- and IL-22 (show IL22 Proteins)-secreting myelin specific CD4 (show CD4 Proteins)(+) T cells resistant to corticoids are associated with radiological activity of multiple sclerosis in early stages of the disease, mainly among Afrodescendant patients who, normally, have worse prognosis.
Studies indicate that all myelin basic protein (MBP) isoforms are intrinsically disordered proteins (IDPs) that interact via molecular recognition fragments (MoRFs), which thereby undergo local disorder-to-order transitions.
Reduced myelin basic protein-induced CD4 (show CD4 Proteins)+ T-cell autoreactivity in interferon-beta (show IFNB1 Proteins)-treated multiple sclerosis patients may be mediated by monocyte-derived interleukin-10 (show IL10 Proteins)
Negatively charged actin and calmodulin (CaM (show CALM1 Proteins)), as well as basic histone H1.3, inhibit MBP (show MBL2 Proteins) hydrolysis by competing with the proteasome and MBP (show MBL2 Proteins), respectively, for binding their counterpart.
data reveal the first case of a pathophysiologically important autoantigen as a ubiquitin-independent substrate of the 26S proteasome (show Psmd4 Proteins).
Single nucleotide polymorphisms on genetic loci SOD2 (show SOD2 Proteins), MBP (show MBL2 Proteins) and C8orf42were not found significantly associated with advanced age-related macular degeneration in a Chinese cohort
Concentrations of MBP did not increase after injury in all age groups
results provide a detailed picture of the MBP-CaM (show CALM Proteins) interaction, including a 3D model of the complex between full-length proteins
MBP-hydrolyzing antibodies may play an important role in multiple sclerosis pathogenesis
Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase (show CDK7 Proteins) activities.
trehalose completely avoid autocatalytic cleavage properties of MBP up to 4 days of incubation at 37 degrees C and pH 7.4.
formation of an imine between inflammatory-derived aldehydes can lead to structural changes in MBP and a decrease in myelin stability
results provide a detailed picture of the MBP-CaM (show KRIT1 Proteins) interaction, including a 3D model of the complex between full-length proteins
MBP can induce a dihydrocholesterol-dependent segregation of phases that can be further regulated by the electrolyte concentration in the subphase and the composition (type and proportion) of non-sterol lipids.
Bovine MBP priming reduces expression of Foxp3 (show FOXP3 Proteins) via nitric oxide in inducible nitric oxide synthase (show NOS2 Proteins)-deficient mouse T cells.
investigation of bovine myelin basic protein binding to triphosphoinositide
There is a developmental regulation of posttranslationally modified forms of myelin basic protein into specific membrane microdomains.
These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated high phosphorylation of SH-binding proteins, including MBP and tau protein.
to further characterize the mechanism regulating mbp transcription, study defined M3 structure/function relationships; multiple M3 regulatory element combinations were found to drive expression in oligodendrocytes and Schwann cells with a minimal 129 bp sequence conferring expression in oligodendrocytes throughout myelin elaboration, maintenance and repair
Results show the expression of sncRNA715 in Schwann cells and its inverse correlation with Mbp mRNA in cultured cells and the sciatic nerve. Its inhibitory effect on MBP was confirmed in differentiating primary Schwann cells.
Results suggest that GAL (show GAL Proteins) is a regulator of myelination, as demonstrated by MBP synthesis, and may be one of the myelination promoters
Data indicate that 18.5 kDa myelin basic protein (MBP) segment upstream of the primary SH3-ligand is involved in interaction.
Data suggest that prenatal alterations in expression of various fetal brain proteins (including up-regulation of Mbp) are associated with aberrant behavioral characteristics of transgenic mice that model autism-like behavior.
Data indicate a role for myelin basic protein (MBP) isoforms in protein-protein interactions during membrane and cytoskeletal extension and remodeling in oligodendrocytes (OLGs).
Disappearance of 21.5 pMBP (show PGRMC2 Proteins) corresponded to demyelination and its reappearance corresponded to prevention of demyelination.
Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha (show PKCa Proteins)-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP.
Myelin basic protein cleaves cell adhesion molecule (show MCAM Proteins) L1 and promotes neuritogenesis and cell survival.
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
myelin basic protein
, myelin A1 protein
, myelin membrane encephalitogenic protein
, 20 kDa microtubule-stabilizing protein
, microtubule-stabilizing protein
, Golli-Mbp; myelin basic protein
, Golli-Mbp; myelin basic protein; myelin basic protein S
, MBP S
, myelin basic protein Golli-mbp
, myelin basic protein S
, myelin deficient