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Myelin Protein Zero-Like 2 (MPZL2) ELISA Kits

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Additionally we are shipping MPZL2 Antibodies (57) and MPZL2 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human MPZL2 MPZL2 10205 O60487
Anti-Mouse MPZL2 MPZL2 14012  
Anti-Rat MPZL2 MPZL2 300679  
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More ELISA Kits for MPZL2 Interaction Partners

Human Myelin Protein Zero-Like 2 (MPZL2) interaction partners

  1. CLCA2 (show CLCA2 ELISA Kits) links junctional adhesion molecule EVA1, to cytosolic signaling proteins that modulate proliferation and differentiation.

  2. Findings highlight Eva1 as a novel regulator of GIC function and also provide new mechanistic insight into the role of noncanonical NF-kappaB (show NFKB1 ELISA Kits) activation in GIC.

  3. EVA (show SLC26A4 ELISA Kits) is expressed in human choroid plexus epithelial cells and CD4 (show CD4 ELISA Kits) T lymphocytes and regulates CD4 (show CD4 ELISA Kits)+ T lymphocyte adhesion to human choroid plexus epithelial cells in vitro. These data suggest a novel mechanism to regulate CNS immune surveillance.

Mouse (Murine) Myelin Protein Zero-Like 2 (MPZL2) interaction partners

  1. EVA deficiency results in increased experimental autoimmune encephalomyelitis disease severity. EVA-knockout Mice have normal immune system development and choroid plexus morphology.

  2. modulation of Eva1 expression in thymocytes is crucial for lymphocyte physiological developmental progression and stromal differentiation

  3. These results suggest that EVA expressed in choroid plexus cells may regulate the permeability of the blood-CSF (show CSF2 ELISA Kits) barrier.

MPZL2 Antigen Profile

Antigen Summary

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain\; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with MPZL2

  • myelin protein zero-like 2b (mpzl2b) antibody
  • myelin protein zero-like 2 (MPZL2) antibody
  • myelin protein zero-like 2 (Mpzl2) antibody
  • cb837 antibody
  • Eva antibody
  • Eva1 antibody
  • mpzl2 antibody
  • wu:fb07b02 antibody

Protein level used designations for MPZL2

epithelial V-like antigen 1 , myelin protein zero-like 2 , myelin protein zero-like protein 2

GENE ID SPECIES
336830 Danio rerio
419779 Gallus gallus
699330 Macaca mulatta
10205 Homo sapiens
14012 Mus musculus
300679 Rattus norvegicus
540423 Bos taurus
489384 Canis lupus familiaris
100172793 Pongo abelii
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