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MAL encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids.
Expression of the developmentally regulated proteolipid MAL (show TIRAP Antibodies) is required for the cytotoxic effect of Clostridium perfringens Epsilon Toxin.
MAL (show TIRAP Antibodies) overexpression leads to reduced expression of Mpz and p75NTR (show NGFR Antibodies), despite functional pathways and normal expression of genes important for Schwann cell differentiation.
the exclusion of MAL (show TIRAP Antibodies) from the expanding 2D crystals of uroplakins explains the selective association of MAL (show TIRAP Antibodies) with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
Phagosomal retention of Francisella tularensis results in TIRAP/Mal (show TIRAP Antibodies)-independent TLR2 (show TLR2 Antibodies) signaling.
The specific reduction and mistargeting of MAL protein as a reaction to sulfatide overload may contribute to the pathogenic mechanisms in metachromatic leukodystrophy.
Our results demonstrate a critical role for MAL (show TIRAP Antibodies) in the maintenance of central nervous system paranodes, likely by controlling the trafficking and/or sorting of NF155 and other membrane components in oligodendrocytes.
Our results suggest a functional role for MAL (show TIRAP Antibodies) in peripheral myelination by influencing the expression of membrane components that mediate axon-glia interaction during ensheathment and myelin wrapping.
This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants.
T-lymphocyte maturation-associated protein
, myelin and lymphocyte protein
, myelin and lymphocyte protein, T-cell differentiation protein