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MLF1 encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Additionally we are shipping MLF1 Antibodies (109) and MLF1 Kits (3) and many more products for this protein.
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Human MLF1 Protein expressed in Escherichia coli (E. coli) - ABIN667346
Winteringham, Kobelke, Williams, Ingley, Klinken: Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation. in Oncogene 2004
Show all 2 references for ABIN667346
Data indicte that acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) with NPM1 (show NPM1 Proteins)-MLF1 and AML (show RUNX1 Proteins) with NPM1 (show NPM1 Proteins) mutations showed similar immunophenotypical and molecular features, including gene mutation patterns and gene expression profiling (GEP).
The subcellular localization of full-length human MLF1 is 14-3-3epsilon-independent.
changes in the subcellular localization of NPM (show NPM1 Proteins), due to alterations in the relative abundance of NPM (show NPM1 Proteins) and NPM (show NPM1 Proteins)-MLF1 proteins, may contribute to the enhanced myeloid progenitor activity of Npm (show NPM1 Proteins) +/- cells
Data present the high-resolution crystal structure of this binding motif [MLF1(29-42)pSer34] in complex with 14-3-3epsilon and analyse the interaction with isothermal titration calorimetry.
MLF1 gene rearrangement is associated with acute myeloid leukemia (show BCL11A Proteins).
phosphorylation of 14-3-3 (show YWHAQ Proteins) binding site by MADM (show ADAM10 Proteins)
These findings suggest that an NPM (show NPM1 Proteins)/MLF1 fusion is the primary molecular abnormality in t(3;5) MDS (show PAFAH1B1 Proteins) and AML (show RUNX1 Proteins) with multilineage dysplasia, and that cases with NPM (show NPM1 Proteins)/MLF1 may be clinically distinct from other MDS (show PAFAH1B1 Proteins)-associated disease
Over-expression of MLF1 has little impact on skeletal muscle function in mice; progressive formation of protein aggregates in muscle are not necessarily pathogenic; MLF1 and MRJ (show DNAJB6 Proteins) may function together to ameliorate the toxic effects of mutant proteins.
shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation
Ectopically expressed MLF1 could be responsible for the pathological apoptosis in early myelodysplastic syndrome (MDS (show MECOM Proteins)) patients.
Mlf1 translocates between nucleus and cytoplasm, associates with a novel hnRNP (show HNRNPH2 Proteins), and influences gene expression
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
myeloid leukemia factor 1
, myelodysplasia-myeloid leukemia factor 1
, hematopoietic lineage switch 7