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Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 Proteins (MLLT1)

Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.. Additionally we are shipping MLLT1 Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat MLLT1 MLLT1 301119  
MLLT1 4298 Q03111
Mouse MLLT1 MLLT1 64144  
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Top MLLT1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MLLT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 (MLLT1) Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 (MLLT1) interaction partners

  1. Recurrent mutations within Wilms tumours involve the highly conserved YEATS domain of MLLT1.

  2. Novel splice isoform of Mllt1 is documented and confirmed that both Mllt1 mRNA isoforms are translated. The data support that MLLT1 protein isoforms display distinct stage-specific expression during spermiogenesis and adult tissues.

  3. Data suggest that AT mutated protein ATM (show ATM Proteins)-dependent phosphorylation of ENL (MLLT1) protein functions as switch from elongation to Polycomb (show CBX2 Proteins)-mediated repression to preserve genome integrity.

  4. AF9 and its homolog ENL directly interact with AF4.

  5. MLL (show MLL Proteins)-ENL Interaction with CBX8 (show CBX8 Proteins) Is Required for Efficient Transformation.

  6. Data from a follow-up study in Rome suggest a particularly favorable prognosis for patients with acute lymphoblastic leukemia expressing the MLL (show MLL Proteins)/ENL fusion gene.

  7. Three-way translocation involving MLL (show MLL Proteins), MLLT1, and a novel third partner, NRXN1 (show NRXN1 Proteins), in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12 (show POLE4 Proteins);p13.3;q23).

  8. ENL chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.

  9. determination of the relative positions of MLL (show MLL Proteins), AF4 and ENL genes, in two lymphoblastic and two myeloid human cell lines

  10. In acute leukemias with a t(11:19) translocation, 50% of the analyzed breakpoints were within the MLLT1 gene introns. The MLL (show MLL Proteins) gene was fused to the intact MLLT1 gene by transcriptional readthrough & a splice event, or by trans-splicing.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 (MLLT1) interaction partners

  1. define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL (show MLL Proteins)-mediated transformation of HPCs

  2. demonstrate BAM11 transcriptional co-activation activity and its functional interaction with Btk (show BTK Proteins)

  3. An intimate association between MLL (show MLL Proteins) and RNA pol II (show POLR2F Proteins) occurs at MLL (show MLL Proteins) target genes in vivo that is required for normal initiation and/or transcriptional elongation.

  4. Overlapping expression of Af9 (show MLLT3 Proteins) with Af4/Aff1 and Fmr2/Aff2 (show AFF2 Proteins), two genes that are also related to neurodevelopmental diseases, as well as with the highly homologous Enl.

  5. Even genetically complex leukemias can be reversed on inactivation of the initiating MLL (show MLL Proteins) fusion.

MLLT1 Protein Profile

Protein Summary

Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.

Gene names and symbols associated with MLLT1

  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 (Mllt1)
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 (MLLT1)
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1 (mllt1)
  • AA407901 protein
  • BAM11 protein
  • ENL protein
  • LTG19 protein
  • MGC84026 protein
  • MLLT1 protein
  • YEATS1 protein

Protein level used designations for MLLT1

myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog , myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog , protein ENL , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1 , ENL/MLL fusion , MLLT1/MLL fusion , YEATS domain-containing protein 1 , leukemia-associated protein MLLT1 , myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog , trithorax

GENE ID SPECIES
301119 Rattus norvegicus
420089 Gallus gallus
447347 Xenopus laevis
485023 Canis lupus familiaris
504458 Bos taurus
702105 Macaca mulatta
740990 Pan troglodytes
100019539 Monodelphis domestica
100065400 Equus caballus
100158574 Xenopus (Silurana) tropicalis
4298 Homo sapiens
64144 Mus musculus
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